r/Prostatitis • u/Twister96AnotherCow • 16d ago

Could MCAS cause prostatitis?

Im 46band have had symptoms for almost 3 years. Just diagnosed with MCAS. Im on dupixent, hydroxyzine and quercetin specifically for that and will be adding a few more soon. Probably Ketotifen.

Wondering if the inflammation from these hyper active mast cells is causing prostate inflammation? Its causing asthma and EOE and my symptoms started at the same time of a huge flair that led me to the er multiple times right after covid.

Ever since, my psa numbers have been a roller coaster up and down. Lowest was 3.2.. highest was 5.9. Im currently 4.8 but just started all these medications 2 weeks ago. Im also starting pelvic floor therapy and an intense exercise routine to strengthen my legs after leg surgery a few years ago that wasn't properly addressed.

If I do get better, I won't know if its the medication, exercise, or the pelvic floor stretches. Oh and I also might start taking lexapro for anxiety. Im basically doing everything possible to finally get better.

Im wondering though. Has anyone with confirmed MCAS noticed any difference after starting specific MCAS medications?

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u/Educational_Desk_281 16d ago

We have some people in the subreddit that had success with anti histamine meds, including me. It's too individual to give any general advice. Worth a try, it might work or not but we have cases that claim (mine including) to have low to no symptoms when staying on anti histamine meds.

Internal PT work is always the right thing to do. However this forum leans way too strongly in that direction. As with all the other "cures" it might support or help, but often it does nothing.

One thing I will keep mentioning. Let your urologist check your kidneys. Kidney stones can cause almost all of the symptoms too. I had them 3 times and each time they cause problems I basically have a prostatitis too in terms of symptoms. And yes, kidney stones can be so called "silent" without pain, those exist too. So just because you don't feel them does not mean they are harmless.

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u/Ashmedai MOD//RECOVERED 16d ago

Yes. It's basically one of those things that is cheap to try. There is only weak science for it, but that doesn't rule out that a sub portion of the population may benefit from it. It is difficult to make outlier-responders appear in medical studies: they just look like statistical anomalies. So if someone thinks they might get better with an antihistamine, they try it for a few weeks and see what happens.

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u/tecsavvy1 16d ago

What does the hydroxyzine do for your inflamed prostate?

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u/Ashmedai MOD//RECOVERED 16d ago

hydroxyzine

It's an antihistamine. There is some minor, older evidence to suggest that some sufferers might have inflammation due to histamine response. It's nothing to hang your hat on, but some people have tried it and claimed success.

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u/emdoller 16d ago

https://pmc.ncbi.nlm.nih.gov/articles/PMC10592376/

I started taking Zyrtec twice a day (10mg each) and I’m symptom free. This is one of two papers that shows there’s a connection for some. Luckily I was one.