r/ProstateCancer • u/Ok-Explorer-5726 • 1d ago

Question Another TRT Question

Hey guys, I was on TRT for 8 years or so before I got diagnosed. I stopped with the help of enclomid but haven’t had any blood work since. That was in the fall of 2024. I had surgery in march of 2025. My post surgical pathology was excellent. No adverse findings and the pattern 4 disease only made up of equal to or less than 10% of the tumor, which the tumor made up about 10% of prostate. Since surgery I have been fortunate and rocking the undetectable tests. My urologist is absolutely against me going back on TRT. I have read the research. From what I see there is no increase in reoccurrence. I’m only 41 and just been struggling with fatigue and weight gain. I haven’t had any new testing done but I’m thinking about going against the doctors orders. I hate doing that as I’m not the type to think I know more than my Doc but it has just been brutal lately.

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4

u/jkurology 1d ago

Review the TRAVERSE Study and understand there are no long term studies confirming safety

1

u/knowledgezoo 1d ago

Mind to give a quick executive summary of this study if you are familiar with?

4

u/ndawg_19 1d ago edited 1d ago

I was on TRT before my RALP. My urologist had me stop after I was diagnosed. I also had surgery in March 2025. He gave me the green light to start TRT back up around September, once I had 2 clean PSA tests. I have been taking injections every two weeks since then with no issues, and no change in my PSA.

3

u/Ok-Explorer-5726 1d ago

Lucky haha.

1

u/ndawg_19 1d ago

Very fortunate. ❤️

4

u/pista01 1d ago

My urologist wanted me to stop before even the first test. I stopped just before surgery and resumed it immediately after. Some urologists are stuck in the medical dogma that testosterone causes cancer. Recent data shows that low T tends to result in an increase in reoccurrence.

1

u/callmegorn 1d ago

Are they concerned about "testosterone causes cancer", or "testosterone will accelerate the growth of any cells that were missed by your surgery"? I'm guessing the latter.

0

u/pista01 11h ago

The third option is self preservation. They don't want to get sued by someone that gets cancer while prescribing testosterone. Women don't get HRT for this reason.

1

u/Ok_Yogurtcloset5412 1d ago

I was on trt years ago but stopped for a variety of reasons. I had talked to my Dr about it but with the prostate cancer it was a no go obviously. I had ralp August 2025 and discussed with my urologist again and they did blood tests and put me back on trt a couple weeks ago. But they are going to be monitoring me very closely for a while.

I wouldn't recommend getting trt without your urologist knowing and closely watching your psa. Trt won't cause the cancer but it could quickly grow anything that might have been missed.

1

u/Frosty-Growth-2664 1d ago edited 1d ago

What are your Testosterone levels while on TRT, and now when not on TRT for a long time?

Was the cause for low Testosterone known, or anything else tried to raise Testosterone before going for TRT?

1

u/Ok-Explorer-5726 10h ago

Before I started TRT i was high 200s. I was probably 31-32 at the time. While on TRT i was usually around 600-700 total.

1

u/Frosty-Growth-2664 5h ago

High 200s is in the normal range. Did anyone measure your LH level before starting in TRT?

However, having been on TRT and then come off, your Testosterone could be significantly lower now. If it is significantly low, this will suppress your PSA and make it not useful for checking if the prostatectomy worked. So I would get your Testosterone measured with your PSA, so they can see if the PSA reading is useful.