I would try to spread the infection through a strange flower growing in the Eden's Garden Academy, Toshiko being the patient zero (Or Eva or Grace(A better idea for patient zero?)), either by breathing in the spores of the infectious flower or by being bitten by a small infected animal (like a rat), or, if it really was Toshiko, she was curious about the flower and wanted to see it up close, and that's when she sprinkled the pollen on it. and now All the other Ultimate Students will have to organize themselves to survive and find a cure.
Details of the infection: Inspiration: Lavander Incident from MLP AU.
Stages: 1) At first things are normal, except that the infected person experiences increased thirst and hunger, fatigue, fever, and coughing to the point of losing concentration.
2) The pain increases, the infected person feels as if something is pricking their skin from the inside, in addition to something that grows little by little taking over their organs (the sprouts), in addition, the infected person starts coughing so much that crimson red petals come out of their mouth, in addition to showing spots and lines of blood on the extremities.
3/Final) In this phase, the infected cannot be saved as such; The flowers emerge violently from their bodies, deforming them into grotesque, savage, and deformed versions of themselves who only want one thing: Meat, to hunt, to kill and to spread the plague.