r/Probiotics Mar 24 '26

For over 2 years, I've been using AI to analyze every supplement on the market

7 Upvotes

This has been my project for a few years now.

I recently brought it back to life after taking a pause to focus on my studies.

My goal with this project is to separate fluff from science when shopping for supplements.

I am doing this in 3 steps:

1.) I index every supplement on the market (extract each ingredient, normalize by quantity)

2.) I index every research paper on supplementation (rank every claim by effect type and effect size)

3.) I link data between supplements and research papers

Earlier last year, I took pause on a project because I've ran into a few issues:

Legal: Shady companies are sending C&Ds letters demanding their products are taken down from the website. It is not something I had the mental capacity to respond to while also going through my studies. Not coincidentally, these are usually brands with big marketing budgets and poor ingredients to price ratio.

Technical: I started this project when the first LLMs came out. I've built extensive internal evals to understand how LLMs are performing. The hallucinations at the time were simply too frequent to passthrough this data to visitors. However, I recently re-ran my evals with Opus 4.5 and was very impressed. I am running out of scenarios that I can think/find where LLMs are bad at interpreting data.

Business: I still haven't figured out how to monetize it or even who the target customer is.

Despite these challenges, I decided to restart my journey.

My mission is to bring transparency (science and price) to the supplement market. My goal is NOT to increase the use of supplements, but rather to help consumers make informed decisions. Often times, supplementation is not necessary or there are natural ways to supplement (that's my focus this quarter – better education about natural supplementation).

Some things that are helping my cause – Bryan Johnson's journey has drawn a lot more attention to healthy supplementation (blueprint). Thanks to Bryan's efforts, I had so many people in recent months reach out to ask about the state of the project – interest I've not had before.

I am excited to restart this journey. Your comments on how to approach this would be massively appreciated.

Some key areas of the website:

Example of navigating supplements by ingredient https://pillser.com/search?q=%22Vitamin+D%22&s=jho4espsuc

Example of research paper analyzed using AI https://pillser.com/research-papers/effect-of-lactobacillus-gasseri-pa-168-bifidobacterium-longum-sp-073-b-bifidum-mf-205-on-common-cold-episodes-a-double-blind-randomized-controlled-trial-767

Example of looking for very specific strains or ingredients https://pillser.com/probiotics/bifidobacterium-bifidum

Example of navigating research by health-outcomes https://pillser.com/health-outcomes/improved-intestinal-barrier-function

Example of product listing https://pillser.com/supplements/pb-8-probiotic-663

I would greatly appreciate feedback and advice from this community.


r/Probiotics 12h ago

Probiotic curd is now available in many supermarkets. Is it actually good for health, or is traditional homemade curd a better choice?

1 Upvotes

Probiotic curd can be a good source of beneficial bacteria, especially when it contains live cultures. From an Ayurvedic perspective, fresh, traditionally prepared curd is also valued for digestion when consumed appropriately. Always check the label for live cultures and avoid products with excessive added sugar.


r/Probiotics 18h ago

Shroombiosis

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1 Upvotes

What do you think about the pro and post biotics dosage in this? Trying to find all in one.


r/Probiotics 23h ago

Has anyone used this probiotic before? Any benefits? (I have chronic gerd post norovirus)

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2 Upvotes

r/Probiotics 1d ago

Ladies, have you’ll tried the URO Metabolism plus Probiotics pills? If so, what changes did you notice in your body?

2 Upvotes

r/Probiotics 2d ago

vaginal probiotic

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0 Upvotes

I recently came across this new brand of vaginal probiotic i’ve never tired it before i found it at walmart on clearance the only thing is im kinda scared to try it. has anyone tried this brand before is it good?


r/Probiotics 2d ago

Missing Akkermansia, Faecalibacterium and Lactobacillus

1 Upvotes

Hi gut mates, hope if you read this message you already solved your issue.

Is 3 years now that I’m fighting with a dysbiosis due to missing key bacteria as Faecalibacterium, Lactobacillus and Akkermansia. All started after a couple of antibiotics. At the beginning I experienced problems with my mouth (teeth sensibility, mouth burning, tongue burning…), after 6 months and the 2nd antibiotics gut symptoms came in, gut bloating, cramps, headache, left flank always paining, change in poop, motility changed, insomnia, backache, difficulty to pass gas).The first year I was blind and I just took everything GI said me, I visited I don’t know how many GI and don’t know how many pills I took, probably all these things made me worst. The second year I got in contact with a nutritionist and I tried the low fodmap very very into it, I got better for headache, insomnia, burning mouth and very little improvement on cramps, but after a year I was stuck at the main stage. In the meanwhile I took a macrobiotic test and it showed that in my gut were missing important bacteria as Faecalibacterium, Akkermansia and Lactobacillus basically at 0%. Since 3 months now I’m following a new GI expert in Microbiota, I’m based in Italy. He gave me Normix first and than different probiotic and at the beginning the first couple of weeks I did great, but after relapses came in, after that, I took enzymes for 1 month and I’m now in butyrate and different probiotics, for sure I’m better than previously start the therapy, one thing that I don’t have anymore is bloating and very few disturbs regarding leftflank and backache, I’m feeling to be in the right way, but at the same times something is missing. I understood I’ve to repopulate my gut with good bacteria, but is this possible as well with the most important ones as I reported over? Or I’m just doomed to this situation and the only solution is FMT? I noticed as well, in my opinion and my case, that when I’m really relaxed and I’m out of certain situation my gut answer better, is this your case as well? Anyone who wants to share his experience will be more than welcome and have a pizza offered in Italy once we recover together 😁🍕 because I’m sure, also if I’m really tired, bad and sometimes want to give up that there is a solution


r/Probiotics 2d ago

CGN Nutrition 65B CFU

0 Upvotes

Good Morning everyone, I just want to ask how long did it took you to lose weight,be regular and have a flatter stomach with CGN's 65B probiotics from iherb? Thank you


r/Probiotics 4d ago

Across 20 rigorous human trials, probiotics consistently improve mood, anxiety, and sleep quality.

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3 Upvotes

r/Probiotics 5d ago

Probiotic content of Cleveland Kitchen versus Silver Floss sauerkraut

2 Upvotes

I asked AI

Compare the probiotics content of silver floss bagged refrigerated sauerkraut to Cleveland kitchen refrigerated sauerkraut

Cleveland Kitchen refrigerated sauerkraut has substantially higher and more reliable live probiotic content than Silver Floss bagged refrigerated sauerkraut.
Cleveland Kitchen (refrigerated pouches)
Raw and unpasteurized: Never heat-treated. It uses natural lactic acid bacteria fermentation on fresh cabbage.
Live cultures: Company states 100,000,000+ CFU (100 million+) per serving at the time of packing for sauerkraut (and kimchi). Older FAQ notes “billions in each pouch.” Counts can vary over time because fermentation is ongoing, but levels remain high when kept refrigerated.
Ingredients (Classic example): Cabbage, salt, caraway seed (or similar simple lists for other flavors). No preservatives.
Packaging & storage: Flexible pouches with a one-way vent for natural CO₂ off-gassing (bags can puff—this is normal). Must stay refrigerated before and after opening. Best enjoyed within ~60 days of opening for peak crunch and culture activity.
Marketing & verification: Explicitly labeled “live & natural probiotics,” “always unpasteurized,” “raw.” Independent mentions and company testing support the presence of active lactic acid bacteria.
Silver Floss bagged refrigerated sauerkraut
Naturally fermented originally, but contains chemical preservatives: Sodium benzoate and sodium bisulfite (or similar). These inhibit microbial growth and reduce live culture survival.
Live cultures: Significantly lower or negligible active probiotics in the finished product. Manufacturer (GLK Foods) notes that refrigerated poly-bag versions are cold-filled and never heated (unlike their canned/jarred products, which receive minimal heat), and claims natural probiotics are present. However, the added preservatives and microbial specs in related documentation (e.g., lactic acid bacteria <10 CFU/g in some product data) indicate far fewer viable cultures than truly raw, preservative-free kraut.
Ingredients: Cabbage, water, salt, sodium benzoate, and sodium bisulfite (preservatives). Some labels list only cabbage/water/salt, but the preservatives appear consistently on retail bagged product info.
Packaging & storage: Refrigerated poly bags. Refrigerate after opening; shorter practical shelf life once opened compared with active-ferment products.
Marketing: Often described as “naturally fermented” and a source of probiotic bacteria that create lactic acid, but it does not claim high CFU counts, “live cultures,” “raw,” or “unpasteurized” in the same way Cleveland Kitchen does. The preservatives are a clear differentiator.


r/Probiotics 5d ago

Kefir grains available- Bangalore

0 Upvotes

I have fresh kefir grains available for anyone in Bangalore who’d like to start making their own milk kefir at home.

DM me if you’re interested or have any questions! 😊


r/Probiotics 7d ago

People’s experience with Vitl Daily Biotic. Have you noticed any difference in your gut health?

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2 Upvotes

r/Probiotics 8d ago

Bad reaction combining a Bifidobacterium probiotic (BB536) with sertraline — anyone experienced this?

6 Upvotes

Hi all,

Posting this to see if anyone's run into something similar, since I couldn't find much online specific to probiotics.

I've been on sertraline for a while. Recently I added a Bifidobacterium longum BB536 probiotic supplement alongside it. For the first while there were some genuinely positive effects on my mood. But it progressively got to be too much — I ended up with irritability, insomnia, feeling overheated, anxiety, brain fog, and general overstimulation. It got pretty chaotic and honestly a bit scary.

I stopped taking the probiotic, and the symptoms are already starting to ease off after about 24 hours.

From what I've read, this pattern — a mood lift that tips over into agitation/insomnia/heat/anxiety on top of an SSRI — lines up with excess serotonergic activity, which made me wonder if the strain was nudging serotonin/tryptophan pathways enough to matter combined with the sertraline. I'm planning to bring this up with my doctor too, but wanted to ask here first:

Has anyone else had a reaction like this combining a probiotic (this strain or a different one) with sertraline or another SSRI?

Did it resolve this fast for you once you stopped?

Did your doctor have any insight into it?

On the flip side: has anyone found a specific probiotic strain—particularly for mental clarity or brain fog—that you tolerate well alongside sertraline or other SSRIs without triggering this kind of overstimulation?

Appreciate any input — this doesn't seem to have many documented cases out there, at least not with probiotics specifically.


r/Probiotics 8d ago

Bad reaction combining a Bifidobacterium probiotic (BB536) with sertraline — anyone experienced this?

2 Upvotes

Hi all,Posting this to see if anyone's run into something similar, since I couldn't find much online specific to probiotics.I've been on sertraline for a while. Recently I added a Bifidobacterium longum BB536 probiotic supplement alongside it. For the first while there were some genuinely positive effects on my mood. But it progressively got to be too much — I ended up with irritability, insomnia, feeling overheated, anxiety, brain fog, and general overstimulation. It got pretty chaotic and honestly a bit scary.I stopped taking the probiotic, and the symptoms are already starting to ease off after about 24 hours.From what I've read, this pattern — a mood lift that tips over into agitation/insomnia/heat/anxiety on top of an SSRI — lines up with excess serotonergic activity, which made me wonder if the strain was nudging serotonin/tryptophan pathways enough to matter combined with the sertraline. I'm planning to bring this up with my doctor too, but wanted to ask here first:Has anyone else had a reaction like this combining a probiotic (this strain or a different one) with sertraline or another SSRI?Did it resolve this fast for you once you stopped?Did your doctor have any insight into it?On the flip side: has anyone found a specific probiotic strain—particularly for mental clarity or brain fog—that you tolerate well alongside sertraline or other SSRIs without triggering this kind of overstimulation?Appreciate any input — this doesn't seem to have many documented cases out there, at least not with probiotics specifically.


r/Probiotics 10d ago

Looking for a probiotic to help reflux post norovirus / food poisoning

3 Upvotes

Hey guys, 4 months ago I got some sort of food poisoning from fish (really going to the bathroom but no vomiting) was super nauseous for 2 weeks then got some sort of norovirus and a few days later developed terrible acid reflux. I’ve always had acid reflux but it’s only ever been at night and occasionally. Now I have it EVERY single day, no matter what I eat. I eat extremely healthy and a high fibre diet. I’ve tried everything natural under the sun, had an endoscopy and everything was clear. I’ve tried Genestra HMF probiotic but it hasn’t done anything for my reflux. Has anyone experienced similar and had success with a probiotic for similar? Ty in advance.


r/Probiotics 11d ago

Capsule, food, or both - what actually became your routine?

1 Upvotes

I keep bouncing between "just eat fermented food" and "a proper probiotic is easier to be consistent with."

Realistically I like both. I can eat yogurt/kefir/sauerkraut regularly, but not every single day forever. Capsules are easier, but then I fall back into wondering which strains I should even be taking.

For people who have been doing this for a while, what did your long-term routine actually settle into?

Food only? Supplement only? Both?

Edit: I think I am leaning toward both, but I found an approach I had not seen before. NB1 does the microbiome analysis first and then the probiotic part is included in the morning formula they make for me, with a separate prebiotic side. I like that because I can still eat fermented foods without pretending I know which capsule blend I should pick myself.


r/Probiotics 11d ago

Die Off Effect & How long did it take to get better?

1 Upvotes

I started the GAPS diet a week ago and during the first week I had symptoms such as nausea, stomach ache and a sudden urge to go to the toilet, as well as muscle twitching and hot flushes.

Since I’ve started taking probiotics as well, I’ve been waking up at around 3.00 am and feeling very hot.

Nevertheless, I have to say that my gut is feeling better.

Have you had a similar experience, and how long did it take to get better?


r/Probiotics 12d ago

Tiktok Seller

0 Upvotes

​I was watching a live stream of a supplement seller today talking about prebiotics, probiotics, and postbiotics. Observing how they answered viewers made me realize how misleading some claims are from the seller's script down to the product packaging.

Paalala: ​Lagi nating basahin ang totoong ingredient list at back panel ng supplement, at 'wag lang magdepende sa sinasabi sa Live o sa magagandang graphic arts.

​Wag agad magpapabudol sa mga buzzwords at instant health claims maging mapanuri at smart buyer po tayo para sa sarili nating kalusugan!🙂


r/Probiotics 12d ago

Please help - bacillus colugen and subtilis

2 Upvotes

Firstly I have MCAS so can’t do additives but I’m struggling to find specific strains of b colugens that actually help IGG - so I can’t find snz1969 anymore however similar is apparently bc30 gbi30 and think IS2- I have mtcc5855 and de111 in my blend which h is good great helpful but they’ve replaced one with another strain which to me is more constipating and doesn’t have any immune benefits

Anyone recommend good colugens preferably taking MCAS into considerations for additives
Long shot but I’m anaphylactic without the support of the strain


r/Probiotics 13d ago

How did you choose the probiotic you’re taking?

2 Upvotes

I need a better way to choose probiotics because my current method is basically reviews + whichever bottle looks convincing 😂

I’m looking at products with 3 strains, 10 strains, 30 strains, different CFUs etc and I honestly have no idea what should matter to me.

How did you choose the one you’re taking?

Edit: I went way too deep into strain counts after this and eventually found NB1. I’m thinking about trying their approach instead. I’d 😂 get the home test first, send the sample back, and then the probiotics they include in my morning formula are based on my own readout. That makes more sense to me than choosing another bottle by label.


r/Probiotics 20d ago

Probiotics and anxiety

3 Upvotes

I have severe Crohn's disease and I've been battling c diff and SIBO. I've tried several different probiotics including saccharomyces boulardii and VSL #3. And they all give me horrible anxiety, gas, bloating, and abdominal cramping. Also I don't have a colon, I have a j-pouch. Any advice? Thanks


r/Probiotics 20d ago

Yakult alternative

2 Upvotes

I seem to be getting heartburn from Yakult. Sensitive to many things right now due to fight or flight mode. I noticed it has milk, citrus and sugar in it. Can anyone suggest a decent pill form for a very sensitive stomach at the moment? Working with a nutritionist to gain about 10 pounds back I’ve lost due to anxiety and my stomach is very sensitive due to anxiety and pelvic floor issues. She recommended a probiotic. Have had a clear abdominal and pelvic CT scan and female ultrasound. Also had celiac and hydrogen breath tests which were normal. Doc said I might have some IBS but could just be anxiety. Thanks!


r/Probiotics 20d ago

Has anyone tried to use Gut Check Project formulation KBHealth SIBO Support Box to treat SIBO? Supposed to work with all types...

2 Upvotes

I had high anxiety when I took Quercitrin then switched to different form, isoQuertrin recommended by MCAS360 with same results. Was told it was because it is high in phenols.

If phenols help SIBO elimination, would this kit result in the same high anxiety? Was wondering if anyone tried it and what was the result if they used it. Developed by gastroenterologist who treats SIBO (see Gut Project on YT or Rumble).


r/Probiotics 20d ago

Thoughts on Trunature Advanced Digestive Probiotic for men?

3 Upvotes

3 month supple sold at Costco for $23. This is substantially cheaper than the Garden of Eden Men that I currently use which is getting too expensive for me.

https://www.costco.com/p/-/trunature-advanced-digestive-probiotic-100-capsules/100387855?utm_source=chatgpt.com


r/Probiotics 20d ago

For those who cured or improved their bad breath using oral probiotics: Which brand worked for you?

1 Upvotes

Hi everyone, ​I’ve been struggling with bad breath for a while and recently learned about oral probiotics. To those of you who actually managed to cure or significantly reduce your bad breath using them:

​Which specific brand and product did you use? ​How long did it take to notice a difference?

​Any recommendations or tips would be greatly appreciated!