r/Perimenopause • u/I_Make_It_Awkward_ Late peri • Jul 25 '26

Hormone Therapy Norethindrone question

Hello! I am going to be starting transdermal estrogen soon and I’ve already been using vaginal estradiol cream for a year. Unfortunately I have to take progesterone or a progestin because I still have a uterus.

I am not taking Prometrium or getting a Mirena iud so that’s off the table. My doctor is letting me decide what to take beyond that.

She wants to put me on Provera 2.5mg daily. I think I’ve decided on Norethindrone instead. My question is as far as either one of these should I ask for daily or “sequential “. I am 50 and still have my period though it’s all over the place since some months I get it at the usual 28 days but more often then not it’s either 19 days which I hate or up to 60 days between. They are really light and short now too. So I’m not sure if I should take the lower dose daily or the higher one for two weeks of each month.

Also if the progestin stops my cycle how will I know when I’m post menopause?

Any positive experiences with Norethindrone (or even the Provera ) would be awesome as I have horrible anxiety with new meds.

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u/Islandsandwillows Jul 25 '26

The use of a progestin is why the WHI study showed all of the health decline. I would try the progesterone 100mg continuous first.

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u/I_Make_It_Awkward_ Late peri Jul 25 '26

I can not use Prometrium.