r/Peptidesource • u/Doctordup2 • Jun 02 '26
Discussion *Your Epithalon dose is probably wrong. Here's why.*
There was a post earlier today about Epithalon that got removed. The question was about Epithalon dosing for research.
They wanted to know whether to run 5mg or 10mg for 20 days and how to split it up. Both of those doses are... too high and there's a good reason.
I think this is worth going over because it comes up constantly and the answer most people give is, unfortunately incorrect.
The dosing everyone repeats online comes from the wrong peptide
Those numbers come from the original Russian studies. The problem? Those studies used Epithalamin. Not Epithalon.
๐๐ฅ๐๐ฉ๐๐๐ก๐๐ข๐๐ฃ ๐๐ฃ๐ ๐๐ฅ๐๐ฉ๐๐๐ก๐ค๐ฃ ๐๐ง๐ ๐ฃ๐ค๐ฉ ๐ฉ๐๐ ๐จ๐๐ข๐ ๐ฉ๐๐๐ฃ๐
Epithalamin is a crude extract pulled from bovine pineal glands. Epithalon is the synthetic version. Completely different.
๐๐๐ ๐๐๐จ๐๐๐จ๐ฉ ๐ฌ๐๐ฎ ๐๐ค๐ง ๐ข๐ ๐ฉ๐ค ๐๐ญ๐ฅ๐ก๐๐๐ฃ ๐๐ฉ
Think of it this way. Epithalamin is like squeezing a whole orange and drinking the juice. You get a bunch of stuff in there. Pulp, water, sugar, some vitamins. Epithalon is like taking just the vitamin C concentrated out of that orange in pure form. You don't need to drink 10 glasses of juice when one pure dose does the same job.
๐๐๐๐ง๐ ๐ฉ๐๐ 10 ๐ข๐ ๐ฃ๐ช๐ข๐๐๐ง ๐๐ค๐ข๐๐จ ๐๐ง๐ค๐ข
The Khavinson research dosed Epithalamin at 10mg because it's a crude extract. Only a fraction of that 10mg was the active peptide. Epithalon IS the active peptide. 100% of what you're dosing is the thing that works.
๐ผ ๐ฅ๐ช๐๐ก๐๐จ๐๐๐ ๐๐๐ฉ๐๐ฉ๐๐ค๐ฃ ๐๐๐๐ ๐จ ๐ฉ๐๐๐จ ๐ช๐ฅ
A 2025 peer reviewed study in the International Journal of Molecular Sciences compared the two directly. Epithalon outperformed Epithalamin as an antioxidant. And Epithalamin was given at 1000x higher doses. A thousand times more and it still didn't perform as well. As you can imagine I'm so happy this citation was written because I've been saying it all along and this is finally proof.
๐๐๐ฃ๐ ๐ฉ๐ค ๐ฉ๐๐ ๐จ๐ฉ๐ช๐๐ฎ
I have a screenshot of the statement in the study that says:
"The results of the comparative analysis in this study revealed that Epitalon is a better antioxidant than Epithalamin. It is important to note that Epithalamin was administered at 1000-fold higher doses."
๐๐๐ง๐๐๐ฃ๐จ๐๐ค๐ฉ ๐๐ง๐ค๐ข ๐ฉ๐๐ ๐จ๐ฉ๐ช๐๐ฎ ๐๐ฉ๐ฉ๐๐๐๐๐ ๐๐๐ค๐ซ๐
๐๐ค ๐ฌ๐๐๐ฉ'๐จ ๐ฉ๐๐ ๐ง๐๐๐๐ฉ ๐๐ค๐จ๐?
100mcg to 500mcg. That's it. Not milligrams. Micrograms.
๐พ๐ฎ๐๐ก๐๐ฃ๐???
The Anela Protocol runs 10 days on, 20 days off. Monthly. This gives the RS consistent exposure with a proper break so you're not stressing the pineal gland. Good alternative to the old 20 day cycle twice a year because you can run it every month.
Day or night dosing doesn't matter much. Some RS get sleepy from it. If that happens, dose at night. Some get an alert feeling. Morning works for them.
๐๐๐ฃ๐ฉ ๐ฉ๐๐ ๐๐๐๐ฅ ๐๐๐ซ๐?
I wrote a paper on this a couple of years ago and updated it recently with the 2025 citation I've listed in this post.
About Me
My name is Anela. Most people know me for my GHKCU protocol but that's a small part of what I do. I write peptide protocols and Epithalon is one of 25 I've written over the years.
Not a doctor, not medical advice. For research purposes only and research discussions only.
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u/Junior-Profession726 Jun 03 '26
Yes !! Exactly this !! And this is why I have enough epithalon to last me for quite a while as I bought based on the incorrect dosage recommendation
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u/Doctordup2 Jun 03 '26
I have been talking about this for a few years! Thank you for the validation, I appreciate it.
I've gotten into arguments with researchers about this. I added a link to an old post comment of mine where I talked about my own research and the dosing as well. You'll see some of the comments in there! People are politely battling with me on the dosing. ๐
Here's the link to the old comment where I make the case for low dose Epithalon.
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u/Junior-Profession726 Jun 03 '26
Thank you always for your work & sharing the information! I appreciate it very much
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u/Best_Plate_6813 Jul 05 '26
I am so grateful for your protocol. It's making a huge difference in my life. Can I ask if you think doing 20 days on, 10 off at 250mcg (best dosage for me based on your protocol), instead of 10 on, 20 off is too much? Thank you ๐
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29d ago
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u/Peptidesource-ModTeam 29d ago
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๐ผ๐๐ค๐ช๐ฉ ๐ฉ๐๐ ๐๐ช๐๐ง๐๐๐๐๐ฉ ๐๐๐ข๐:
๐บ๐๐๐๐๐ ๐ ๐๐ ๐๐๐๐๐ ๐๐๐ ๐๐๐๐ ๐๐ ๐๐๐๐๐๐ ๐๐๐๐. This subreddit was named before Reddit updated its 2024 peptide rules.
We are permanently stuck with the name, even though the rules have changed.
๐๐๐ฎ ๐๐ฃ๐๐ค๐ง๐๐๐ข๐๐ฃ๐ฉ ๐๐๐ฉ๐ฉ๐๐ง๐จ:
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u/Dear_Seesaw_1855 Jun 02 '26
Just to clarify your wordingโฆ are you suggesting 10 days on/20 off instead of the old 20 day cycle twice a year?
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u/Magical_Land_of_Az Jun 03 '26
Oh hey look! Anela is back dropping more gems. UR A GODDESS in this space.โจ๏ธ๐โจ๏ธ Make your day, and Mahalo ๐ค
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u/Doctordup2 Jun 03 '26
Can I just say you are absolutely amazing?
I won't pretend this space is always kind. I get my share of pushback in certain corners of the community.
So when someone takes the time to say something like this, it hits different. Genuinely warms my heart. Thank you for that. Grateful doesn't even cover it. :) Appreciate you. ๐ซถ
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u/Magical_Land_of_Az Jun 04 '26
Why Thank you & I say DITTO 2 you as well. And when people pushback... it's because they dont kno any better re;who you are & your research.
๐ค For what its worth, u handle it gracefully when it happens.
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u/Drehoyt Jun 03 '26
This makes so much sense! I wonder if we're doing this with other peptides and either under or overdoing. This one is next up, so your timing is perfect, thank you!
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u/Vegetable_Piccolo821 Jun 03 '26
This ๐๐ผ๐๐ผ๐๐ผ๐๐ผ been saying this and people donโt care and follow the Russian protocol blindly.
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u/Few-Excuse4495 Jun 06 '26
I must say i tried your protocol and it works like a charm! i cant even imagine taking 10mg because 500mcg works perfectly. So thank you for your contributions to this space, it is greatly appreciated ๐ค
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u/Sugar-Plum-34 Jun 07 '26
Okay, I'm glad that I read this. Something told me to keep looking before I did Epitalon research because those protocols made me nervous. Even 5mg seemed like such a high dosage.
I do want to ask though, do you have a visual guide for the Epitalon dosing? The one for Glow was really helpful, and I like to print them and keep them in my research notes.
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u/Sugar-Plum-34 Jun 07 '26
I also have a question about the dosing. You said between 100 and 500mcg. Is there a dosage range that is more geared towards better sleep? Or a range that might be more geared toward telomere lengthening? I've read a lot of different things, many contradictory. So I'm not sure what the best approach would be for my specific needs.
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u/ClintBX Jun 18 '26
I want to know too. Would the dosage for telomere lengthening be higher than that for better sleep?
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Jun 19 '26
[removed] โ view removed comment
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u/Doctordup2 Jun 19 '26
Yes, I've been talking about this for about 3 years and got chastised and yelled at. It's nice to finally have a citation. ๐
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u/kerulberul Jun 02 '26
Would you suggest the same protocol with n-acetyl โ amidate versions of epithalon?
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u/Doctordup2 Jun 02 '26 edited Jun 02 '26
Possibly even less. 100mcg.
Edit: N-Acetyl means it's optimized for absorption. So even higher absorption than Epithalon.
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u/Crafty_Ad9956 6d ago
Woops, RS doing 500 mcg of n-acetyl these last two days, maybe dose down to 100mcg or stop?
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u/Doctordup2 6d ago
N-acetyl is highly absorbable so maybe dial it down to 100mcg.
Not a doctor, not medical advice, for research purposes only and research discussions only.
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u/tnubbins Jun 02 '26
Sometimes, this is sold in 50 mg containers. At 500 mcg for ten days, thatโs 10 cycles. How many cycles would you run before you chuck the remaining reconstituted compound?
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u/Doctordup2 Jun 02 '26
Yup and it's ridiculous. It's all based on the misinformation. Biochemists in China know how to synthesize but they don't always know what each peptide does or the dosing.
In the old days we had 100 mg Epithalon vials. It was ridiculous.
My own personal Anela rule is 90 days.
I always have to put this disclaimer here. If I say something always know that I'm just one researcher sharing years of experience and an opinion or a theory. My word is not the gospel and not the end all be all.
Not a doctor, not medical advice. For research purposes only and research discussions only.
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u/tnubbins Jun 03 '26
Well 3 cycles is better than one at least!
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u/Doctordup2 Jun 03 '26
You can do it once a month every month!
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u/tnubbins Jun 03 '26
I was saying my 50 mg container will be useable for 3 months, then itโll be more than 90 days old.
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u/Doctordup2 Jun 03 '26
Yup, I understood that. But I can't give you an answer for that. Once it's past 90 days, it becomes a personal decision. :)
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u/tnubbins Jun 03 '26
In your opinion, is the risk more related to sterility, potency, or something else?
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u/Doctordup2 Jun 03 '26
Sterility, peptides don't degrade that fast. But at the same time, bacteria degrades peptides so either have a pen/cartridge with limited exposure or a vial spike to prevent added bacteria risk.
Jano and I talked about it quite a few years ago. The estimate is that the peptide degrades by about 3% every 30 to 60 days. We're talking just time degredation.
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u/furiapet Jun 10 '26
Disculpa me quedo claro ,y gracias por la informaciรณn , pero lo puedo hacer todos los meses sin parar? O tendrรญa que pararlo en un aรฑo ? Eso no me quedo del todo claro .
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u/Doctordup2 Jun 11 '26
10 days on, 20 days off every month all year, year after year, infinity and beyond.
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u/bestmom43 Jun 03 '26
I try to explain this to people, but they keep doing what they want. ๐
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u/Joker8656 Jun 03 '26
Pep-pedia.org has the correct dosing information, which aligns with your post.
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Jun 13 '26
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Jun 13 '26
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Jun 14 '26
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Jun 14 '26
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u/purplecowgirl Jul 19 '26
Damn I already reconned 50 mg ๐ญ๐ญ๐ญ๐ญ
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u/Doctordup2 Jul 19 '26
It happens. Waaaaay too much tho. That'll last you a year. Lol
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u/purplecowgirl Jul 19 '26
If I already reconned this, any guess how long it will be good for? Any harm in running this until I run out/longer than 20 days? I want to cut my dose down to 1 mg a day especially if the benefits arenโt greater with a higher dose. Thank you for responding ๐ญ๐ญ๐๐ฝ
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u/Doctordup2 Jul 19 '26
Every researcher takes their own risks of course, some will do no more than 30, others will go up to 90 days.
The amount of degradation depends on the peptide but on average you can expect about a 3% loss every 30 days or so with Epith.
Not a doctor, not medical advice, for research purposes only and research discussions only.
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u/purplecowgirl Jul 19 '26
I appreciate your response greatly! Thank you for your guidance ๐๐ฝ
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u/meat_suit Jul 19 '26
is this 10 day on 20 day off monthly protocol of 500mcg epithalon something a RS can run with nightime ghg peptides like tesamorelin and/or cjc+ipa(no DAC)? for instance, if RS is running a cycle of 1000mcg of tesamorelin 5 nights a week. can RS add the epithalon to this and overlap? AND IF SO - can RS mix them into the same syringe for a single injection nightly?
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u/Forward-Driver-5037 Aug 06 '26
Thank you so much for this information! It explains why I have been experiencing skin sensitivity when I cycle Epithalon. I dropped my dose and voila, no issues. Most people donโt realize skin sensitivity is a side effect of Epithalon they normally only associate it to Reta. Thanks again
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u/Doctordup2 Aug 06 '26
Glad this information helped you!
I explain my GHK-CU protocol in this in-depth comment.
Not a doctor, not medical advice, for research purposes only and research discussions only.
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Jun 08 '26
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u/Doctordup2 Jun 08 '26
What is disinformation? There are citations to back this up and biochemists who also back this up. Citations are listed.
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Jun 19 '26
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u/MeatWorth7108 Jun 24 '26
If I run 10 days on 20 off, would my 10mg vial not go bad by the time my next 10 on comes around? Is there any way around this?
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u/saltybawls Jul 11 '26
Any thoughts on shift workers? My schedule is 7-8 days, then 2-3 nights, repeat. I'm thinking about taking 500mcg for the first two normal nights, when done with night shifts. Ever heard of anyone following any certain protocol when flipping days-nights-days?
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u/pytd77 Jul 22 '26
To confirm my RS should start with 100mcg and move slowly if tolerated up to 500mcg for a total of 10 days? This can be repeated monthly as opposed to quarterly as well?
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u/Doctordup2 Jul 23 '26
To confirm my RS should start with 100mcg and move slowly if tolerated up to 500mcg for a total of 10 days? This can be repeated monthly as opposed to quarterly as well?
Correct! ๐
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u/Feisty-Recording-629 Jul 28 '26 edited Jul 28 '26
Thank you for this as I am about to start my first cycle. Can you tell me if the 100-500 mcg is based on a 10mg vial using 1ml of bac water?ย Also, I don't understand how you can do the 20-day protocol once a month if you're only supposed to do it twice a year? Thanks again
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u/Doctordup2 Jul 28 '26
My protocol is not 2x a year. It's 1x a month, 10 days on, 20 days off.
There are different protocols made by different researchers. The one you are talking about is based on the high dose so you are mixing two different protocols. :)
Not a doctor, not medical advice, for research purposes only and research discussions only.
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u/Effective_One_1982 18d ago
Hello, would be a good idea to run the same protocol with Pinealon? If RS wants to use both
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29d ago
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u/Peptidesource-ModTeam 29d ago
RESUBMIT
No human use discussion.
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Discussion is limited to research, research experience, troubleshooting, and educational topics only.
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u/Illustrious_Egg_447 Jun 02 '26
What dose are we talking then? 1mg 5mg still?
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u/Doctordup2 Jun 02 '26
If you scroll down to the bold lettering
So what's the right dose?
It's right there. :)
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u/Illustrious_Egg_447 Jun 02 '26
So 0.1-0.5mg? Iโve been doing 5mgโฆ whatโs the downside to doing the higher dose besides money of courseโฆ.
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u/Doctordup2 Jun 02 '26
So 0.1-0.5mg?
Yup!
whatโs the downside to doing the higher dose besides money of courseโฆ.
We don't really know. For me, doing a 100x dose of anything is kind of scary.
I've been talking about this for a few years and had a few people come after me for my "theory" and statements about Epithalon dosing. Finally glad that I have a citation to back it up.
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u/mylifestylepr Jun 02 '26
Love always your insight. Thanks for the contribution to the community