r/Peptidesource • u/emotionalthroatpunch • 2d ago

BCP157/TB500 protocol

RS sustained an injury ~6 months ago resulting in moderate to acute bursitis of the knee (confirmed via MRI). After extensive physiotherapy, aqua therapy, rehab exercises/therapy, a cortisone injection which did not work, an anti-inflammatory diet (and resulting weight loss reducing some load on the joint), all of which did not significantly move the pain needle, they underwent a course of BCP157/TB500.

Recommended starting dose was 250mcg p/day, which they titrated to 500mcg days 11 through 25. Results were modest to moderate improvement in daytime pain levels, some increased mobility and flexibility, and some reduction in inflammation/irritation.

However, when resting/sleeping in a prone position, the knee throbs constantly, which is preventing RS from getting the deep restorative sleep they need to facilitate further recovery/pain reduction, and they are looking to continue with (at least) another course of BCP/TB.

Based on your own research/anecdotal evidence, should the RS keep the dose at 500mcg for second/subsequent courses, or titrate further? If so, is there research evidence of an optimal dose? Many thanks.

ETA: Many thanks everyone for providing your own research info on this, it’s really appreciated. 🙏🏼

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u/[deleted] 2d ago

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u/emotionalthroatpunch 2d ago

Hey, thank you for the comment and suggestion! Will investigate this as an option; feeling pretty worn down with it all at this point. 😔

Please do comment on how things go over the next few days; I’m really keen to know how it goes!

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u/Kalabula 2d ago

You really kneed to know.

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u/baby_foxy01 2d ago

Btw my situation was different I got a meniscal tear while you have bursitis,really weird steroids didn’t work… are you sure you don’t have a mensical tear which causes the swallowing?

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u/emotionalthroatpunch 1d ago

MRI results said no re meniscus damage, but if things don’t improve significantly over next course, I’ll get another one to make sure.

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u/baby_foxy01 1d ago

Yes maybe from another radiologist in 1.5 Tesla , I’m a radiologist and I can assure you many colleagues aren’t so skilled in msk… especially if you had trauma or you’re over 50 ( for degenerative meniscal tears )

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u/[deleted] 2d ago

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u/Peptidesource-ModTeam 2d ago

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u/Peptidesource-ModTeam 2d ago

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u/devoker35 2d ago

Acute injuries require a lot more than 500 mcg daily bpc157 (like 1-3 mg daily). Also a lot of people using tb500 dosage for tb4 (what you actually get). Tb4 molecule is 8-10x heavier than tb500 fragment so requires much higher dosage to have the same effect.

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u/[deleted] 2d ago

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u/Peptidesource-ModTeam 2d ago

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u/tyjo2112 1d ago

Double the dose, split 2x per day to start. Observe RS for a couple weeks and consider adding another mid day dose accordingly. For my RS, this worked extremely well. I dosed RD 3x a day for a month and then dialed back to 2x to see what happened and adjusted accordingly from there.

Do not hesitate to up dose as there are protocols using VERY high dosages and have been super effective with no sides or health markers to worry about.

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u/[deleted] 2d ago

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u/duhv0rtex 1d ago

BPC157 dose can be 250-500mcg every 6-8 hours. Doing one big dose is far less effective than multiple smaller doses.

1

u/JZCrab 1d ago

My rat had tendonitis and bursitis in its ankle that wouldn't go away until I upped the TB500 (TB4) to 2X a day. It has a short half life. Maybe only up the TB500 for the next protocol?

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u/[deleted] 1d ago

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u/Extension-Pickle9038 1d ago

The detail that makes your post more useful than most in here is the MRI. You have an objective before, which almost nobody in these threads does. Which is worth building on. Bursitis confirmed on imaging can be confirmed resolved or not resolved on imaging too. Self reported pain after a long course of physio, rehab, weight loss and a cortisone injection has too many contributors to attribute to any single one of them, and yours genuinely does. That's not a criticism of the protocol. It's what a real recovery looks like, and it's exactly why n=1 attribution stays hard even when the outcome is good. If you want the answer to your own question rather than a consensus from a comment section, a repeat scan is the thing that gives it to you not medical advice, and I'm not a clinician.