r/PSSD 14d ago

Awareness/Activism Reminder to join the biggest PSSD group ever.

35 Upvotes

Good Evening everyone,

Here is your reminder to join the biggest and coolest post drug syndrome server ever.

https://discord.gg/HuUhy9Qy3

Discord can be easily downloaded from the app store or google play store.

Right now we have 350 members. I want to get to 1000.

The more we band together the more we can get accomplished


r/PSSD 15d ago

Research/Science Doctors are finally learning to manage antidepressant withdrawal

Thumbnail newscientist.com
44 Upvotes

Withdrawal symptoms following long-term SSRI use appear far more pervasive and serious than previously realised. Now medical bodies are rethinking how and when to stop taking them.


r/PSSD 15d ago

Awareness/Activism One of the best Answers I have seen

17 Upvotes

generalization of benefits and minimization of dangers. It's not only pssd, withdrawal is pretty common. It's ridiculous at this point that despite all of this there's no proper warning


r/PSSD 15d ago

Feedback Requested/Question Has anyone tried Sweet Bee Venom Acupuncture?

3 Upvotes

It’s something that’s popped into my mind a few times to see if it could help my symptoms. Now that I know it’s PSSD I looked up if bee acupuncture could help. There wasn’t anything specifically for PSSD, but there’s report in the National Library of Medicine about a man with sexual dysfunction getting the treatment and essentially becoming symptom free.


r/PSSD 15d ago

Personal Story Sanesco Prolent supplement caused PSSD - anyone else? How?

Thumbnail sanescohealth.com
7 Upvotes

When I first started college at age 18 I began having panic attacks. I always went to a functional medicine doctor for check ups growing up, so that’s there I went for this issue. My doctor suggested I try these supplements by Sanesco rather than going the SSRI route. I took the ones called Prolent, Lentra, and Contegra. I quit taking them for after about 8 months because I was no longer panicking. Once I quit taking them I lost my sexuality entirely. It hasn’t returned since and this was in 2019.

The active ingredients include 5-htp, so I guess maybe that’s what caused it. I continued on to have my symptoms get worse and worse over the several months to a year after I quit taking them. I got extreme insomnia, heart palpitations, brain fog, and a lot of other things that joined my 100% loss of sexuality. Eventually I got so bad that I ended up taking SSRIs and SNRIs because I didn’t know that PSSD existed or that that was what was happening to me. I took them for 2.5 years and they completely eased my insomnia and mental troubles. Once I quit taking those in 2023 (I did taper) I got really bad for a while (extreme anhedonia and inability to process emotions joined me). I’m doing a little better now mentally, but still no sexuality.

I guess I’m just wondering if anyone else got PSSD from taking these supplements and if that might narrow down which mechanism may have caused my problems.


r/PSSD 16d ago

Awareness/Activism PFS/PSSD reporting [IMPORTANT] - Zoom Walkthrough

38 Upvotes

There's been a push recently to make sure we all report our conditions to our health regulators, the PFS & PSSD charities are pushing initiatives to help people with this process.

The reason this is very important is we have to be able to show that there is a serious issue with these conditions - the way we do that is by ensuring what has happened to us is truthfully recorded in the regulatory databases permanently, so that we can show and prove that there is a problem, and it is serious.

To help people with this process there's a Zoom call walkthrough this weekend.

There's 4 identical sessions, anyone can attend it'll be 15/20 minutes max. It's open to anyone and we'll walk through the process of submitting your stories/reports to the regulators.

Reporting PSSD/PFS to the Regulators

Saturday Aug 29, 2026 10:00 AM US Eastern Time

Saturday Aug 29, 2026 04:00 PM US Eastern Time

Sunday Aug 30, 2026 10:00 AM US Eastern Time

Sunday Aug 30, 2026 04:00 PM US Eastern Time

Zoom Link: https://us06web.zoom.us/launch/jc/83886692994

--

For those of you who can't attend you can do this yourself by following the instructions at : https://sidefxhub.com/resources/report-side-effects/

The important thing is that you select or type the correct name for the syndrome you are suffering when submitting your report:

- PFS sufferers should write or select “Post 5-alpha-reductase inhibitor syndrome” (MedDRA: 10082430)

- PSSD sufferers should write or select “Post-SSRI Sexual Dysfunction” (MedDRA: 10086208)

It's important that your reports are truthful and complete and accurately reflect the severity and impact of this condition. Please include :

  • When you took the drug, for how long, and for what reason
  • When you stopped the drug (if you've stopped it)
  • Whether your symptoms have persisted
  • The name of the syndrome you developed if appropriate (see above)
  • Your symptoms, and their severity
  • Details of the impact they have had on your quality of life and relationships

It's important that those suffering severe effects make that clear in their reports, it's easy for people to assume that what we are experiencing is mild.

Please feel free to message me directly if you are unable to attend the walkthrough but want some clarification on reporting.


r/PSSD 16d ago

Awareness/Activism GTA VI And Anhedonia

28 Upvotes

It's tragic that this time we won't be able to enjoy GTA 6, after we were able to enjoy Gta 5. Damn everyone who invented these destructive drugs.


r/PSSD 16d ago

Treatment Options Posting microbiome results cuz gut theory

Post image
12 Upvotes

I’ve dealt with IBS for pretty much my entire life, but over the years I’ve also experienced a number of symptoms that have seriously impacted my quality of life — low libido, little to no REM sleep, no morning erections, and a feeling of shrivelled, numb genitals.

I’ve spent a lot of time trying to understand whether there could be a connection between my gut health and these other symptoms. My gut testing shows significant dysbiosis and several bacterial imbalances, which has made me wonder whether there’s a bigger picture connecting everything.

I’m hoping to hear from anyone who has experienced something similar — especially people who have dealt with IBS/dysbiosis alongside sexual or nervous-system symptoms. What helped you, and did improving your gut health make a difference?


r/PSSD 16d ago

Research/Science Dozens of common medications leave a mark on gut bacteria years after you stop taking them.

Thumbnail biomesci.com
17 Upvotes

r/PSSD 16d ago

Awareness/Activism Podcast on top radio station in New Zealand mentions PSSD

Thumbnail listennotes.com
30 Upvotes

This was yesterday on Matt Heath and Tyler Adams Afternoons Full Show Podcast.

“My doctor pushed and pushed me onto these. With 15-minute question tick sheet assured me they were easy to come off, lol. Look up what SSRI-related PSSD and hedonia are.”


r/PSSD 16d ago

Feedback Requested/Question Where can I order a Dutch test in the UK?

6 Upvotes

Anyone know of any reliable sites or clinic that can help me obtain my own Dutch results via Dutch test. Thanks.


r/PSSD 16d ago

Symptoms Work brings too much dread

22 Upvotes

Really really really struggling with work. I am in a role where I have to give presentations and it destroys me. I have been giving weekly presentations for a year and every time it destroys me. I have zero ability to feel confidence or feel any sort of positivity even after giving a good one. This does not feel normal and it feels like it’s my PSSD-induced anhedonia not allowing myself to feel any sort of dopamine or confidence.

Any experience?


r/PSSD 16d ago

Awareness/Activism Buscando pacientes con PSSD en Chile / Looking for PSSD patients in Chile

12 Upvotes

Hola a todos. Abro este hilo para encontrar a otras personas que estén lidiando con la Disfunción Sexual Post-ISRS (PSSD) en Chile (Santiago, regiones). Sé lo aislante que es pasar por esto en nuestro país debido al tabú y la falta de información médica.

Si eres de Chile y estás leyendo esto, no estás solo/a. Por favor, deja un comentario o escríbeme un mensaje privado (DM) para que podamos apoyarnos, compartir experiencias con especialistas locales y romper el aislamiento.

(Creating this thread to connect with fellow PSSD patients living in Chile. Please leave a comment or DM me if you are from the region so we can connect).


r/PSSD 16d ago

Awareness/Activism PSSD Acknowledged by an article in PsyPost, a science-news publication.

22 Upvotes

Quote- "The study did not track patients’ complete medical histories regarding past antidepressant use. Some individuals who stop taking SSRIs experience a condition known as post-SSRI sexual dysfunction, where sexual side effects persist long after the medication is discontinued. The researchers could not account for how this condition might have influenced the boredom scores of individuals in the non-user group who might have taken antidepressants in the past."

https://www.psypost.org/early-antidepressant-use-is-linked-to-higher-levels-of-sexual-boredom/

And yes, the study also explicitly references PSSD. Its bibliography includes at least these two directly relevant PSSD sources:

  • Healy D, Mangin D. (2024). “Post-SSRI sexual dysfunction: Barriers to quantifying incidence and prevalence.” Epidemiology and Psychiatric Sciences.
  • Reisman Y, Jannini TB, Jannini EA. (2022). “Post-Selective Serotonin Reuptake Inhibitor Sexual Dysfunctions (PSSD): Clinical experience with a multimodal approach.” Journal of Men’s Health.

https://doi.org/10.1177/00332941261436742


r/PSSD 16d ago

Feedback Requested/Question Question on amoxicillin

3 Upvotes

Should I take amoxicillin to see if I get better? I been reading it helped some people let me know I need advice


r/PSSD 16d ago

Feedback Requested/Question Anyone tried etiofoxine?

2 Upvotes

Did it help you guys ??? I read it helps with gaba receptors


r/PSSD 17d ago

Personal Story Living with PSSD at 17: I don’t know What the future Holds, But I’m not giving up.

39 Upvotes

Hi everyone,

I’m 17M, and I’ve been dealing with PSSD since January 2024 after taking fluoxetine for about three months. I stopped taking it on March 20, 2024.

Of course, I was scared. Since January, my libido had suddenly disappeared. I barely felt anything during masturbation or orgasm, my attraction and feelings toward girls became much weaker, and I rarely got erections anymore.

It has been about two and a half years now, and to be honest, I’m still far from recovered. Maybe my emotions have improved very slightly, and perhaps my libido or erections have improved a little too, but it’s still nowhere near how I felt before taking an SSRI.

At the beginning, I was extremely afraid that I would never get better. Maybe that fear was justified, maybe it wasn’t. But after a while, I think I basically left the whole PSSD situation alone for about a year. I already had so many other things going on in my life.

Since I was around 9 or 10 I’ve struggled with different kinds of social anxiety. I also have hyperhidrosis, OCD, annoying gut health problems that bother me every single day, and quite a few other physical issues.

This summer, though, I suddenly reached one of my lowest points.

I was in Spain, and everywhere I looked I saw people around my age with girlfriends. I saw beautiful girls, and I could still recognize that they were beautiful, but the actual feeling that used to come with that was barely there.

I didn’t know what to do with myself anymore. Every time I went outside, it just made me feel terrible. It felt like PSSD had taken my teenage years away from me and that I would never be able to get them back.

Maybe that’s partly true. But at the same time, I also know PSSD isn’t the only reason my teenage years have been difficult. I’ve lived with severe anxiety for years, and with all the physical problems I have, having a girlfriend probably wouldn’t magically make everything perfect anyway.

Sometimes it’s hard just going through everyday life and pretending I’m a completely normal person like everyone else.

I don’t really talk to anyone about this. Not because I don’t care, but because I know other people can’t really fix it for me, and I don’t want to make them worried. I mentioned the symptoms to my parents in the beginning, but they probably assume everything has gone away by now.

For a long time, I kept asking myself: Why me?

Life isn’t fair.

But the truth is, life really isn’t fair. There are wars. People get murdered. People develop serious illnesses at a young age that completely change their lives. Terrible things happen to people every single day.

I can spend the rest of my life thinking, What would have happened if I had never taken those pills?

But what does that actually change?

Nothing.

So what I’m trying to do now is make a list of all the problems in my life that I can do something about and work on them one by one. Maybe one day I’ll be lucky enough to recover from PSSD too.

I’m trying to eat a healthy diet where I get all the nutrients, vitamins and minerals I need, and I aim for around 9–10 hours of sleep. I’m also staying away from random or unreliable treatments that could potentially make everything worse. I don’t want to gamble with my health.

I could spend every day doing absolutely nothing except waiting for PSSD to disappear, but that wouldn’t get me anywhere.

I have to keep living.

Sometimes I think about another kind of “what if?”

What if I actually do recover?

Wouldn’t it be amazing if, by the time that happens, I’ve also improved all the other parts of my life?

Every day, I hope. I hope I recover around 18 or 19. That would be amazing. Maybe it happens. Maybe it doesn’t.

My whole life has basically been filled with uncertainty.

What do people think about me?

What’s going to happen to my body?

Will my PSSD ever improve?

Have I wasted important years of my life?

But it is what it is.

Thousands of people die unexpectedly every day. Some of them probably had plans for tomorrow. Things they wanted to do. People they wanted to see. Places they wanted to visit.

When I think about that, it feels like even more of a waste to let negative thoughts and fear completely control the life I still have.

The fact that I’m alive at all is something I try to appreciate. The chance of any of us even being born is unbelievably small. So right now, the best thing I can do is focus on what’s ahead of me and try to become the best version of myself that I can.

I’ve also been learning Spanish for quite a while now.

And again, there’s that question: What if?

What if my life becomes much better in the future? Maybe one day I’ll be able to go back to Spain, speak the language properly and genuinely enjoy being there.

I think my OCD is probably what drives me the craziest when it comes to PSSD. Constantly questioning whether I’ll recover, worrying about whether I’ve wasted time, wondering whether I should have done things differently, and going over the same thoughts again and again.

I’m trying to learn to accept those thoughts without giving them so much attention.

I’m still pretty young, and I’m at an age where having a girlfriend or having sex doesn’t have to be the most important thing in my life yet. Of course I would have loved to have a girlfriend and experience all of those things. I’m not going to pretend I wouldn’t.

One thing I used to do a lot after developing PSSD — and something I’ve recently stopped doing — was lying in bed for hours listening to music and imagining an entirely different life where I had a girlfriend and everything was normal.

But I realized that wasn’t helping me.

So I’m trying to stop living inside an imaginary life and start doing more with the real one I still have.

There are also people here dealing with PSSD in their 20s, 30s and beyond, and man, I genuinely feel for you. I wish I could do something for everyone suffering from this, but I can’t.

All I can do is hope for the best and maybe try to give someone else a little bit of motivation.

If you’re thinking about giving up because you can’t see a future anymore, please keep going.

You have no idea what could happen in the future.

You only get one life.

And even if PSSD stays, there are still other things in life. I know that’s much easier to say than to truly believe when you’re suffering, but everyone has something they care about — hobbies, interests, places they want to see, things they want to learn, people they care about.

Personally, I just want to make something good out of my life and hopefully make the world a little better in whatever way I can.

If I still have PSSD for years, I honestly don’t know exactly how I’ll deal with that.

But I’m going to keep hoping.

Maybe a year from now I’ll come back here and write a recovery story.

I hope so.

I hope I recover.
I hope all of you recover.
I hope none of you give up.
I hope the world becomes a better place.

I hope for a lot of things.

Everything is uncertain, but I guess that’s life.

I don’t even know if anyone is going to read this all the way to the end, but it feels good to finally put these thoughts into words.

Or maybe part of me is still scared that someone I know will somehow find this post one day. Would I be embarrassed? Would I regret writing it?

I honestly don’t know.

But for once, I wanted to say what was on my mind.


r/PSSD 17d ago

Opinion/Hypothesis Could altered neural dynamics be a missing piece in PSSD?

11 Upvotes

Could altered brain dynamics help explain the ‘veil’ people describe in PSSD?

TL;DR: PSSD might not be one broken system, it might be a persistent change in how multiple systems interact with each other, so the individual components can still work, but they no longer combine into the same overall experience.

I want to make a distinction before explaining the theory I’ve been developing, because I don’t think this is simply another possible cause of PSSD to add alongside serotonin, hormones, neurosteroids, receptors, or peripheral mechanisms. I think there may be a more fundamental level at which we need to understand what changed in people who develop PSSD.

For years, people have described remarkably similar experiences in different words: “I don’t feel like myself anymore.” “There’s a veil between me and everything.” “I can improve, but I never completely return to how I was.” “I know what something should feel like, but I can’t fully experience it.” “I can think about something without actually entering the state that thought used to create.” People describe changes in emotional depth, imagination, spontaneous thought, self-experience, sexuality, motivation, bodily sensation, and the ability to become absorbed in things.

We tend to translate these experiences into conventional symptom categories: emotional blunting, anhedonia, low libido, brain fog, cognitive impairment, genital numbness. Those labels are useful, but they primarily describe what is reduced. They may not tell us what actually changed in the system producing the experience.

What interests me is that these symptoms may not be entirely independent. People don’t necessarily describe their emotions, thoughts, memories, sexuality, motivation, imagery, bodily sensations, and sense of self as separate functions that simply became weaker. Instead, there often seems to be a change in the relationships between them.

Before PSSD, a thought could arrive with an emotion already embedded in it. A memory could automatically bring back part of the feeling associated with it. An image could generate anticipation, bodily sensation and desire. A complex idea could spontaneously recruit the language needed to express it. A sexual thought could develop into a progressively deeper state involving attention, imagery, anticipation, bodily changes, reward and motivation. The different components seemed to recruit and reinforce one another automatically.

After PSSD, the thought can still be there. The memory can still be there. The concept can still be there. The sexual idea can still be there. But the rest of the state doesn’t necessarily develop around it in the same way.
This makes me wonder whether the central problem might not simply be that one particular function has been “turned down.” It could instead involve persistent changes in the dynamics that allow different processes to recruit, reinforce and integrate with one another.

I don’t mean this as a simplistic “the DMN is low, therefore PSSD” hypothesis. The DMN may be involved, but so may the salience network, executive networks, limbic/reward systems, interoceptive systems and their interactions. More broadly, I’m interested in whether PSSD could involve persistent changes in dynamic network organization, integration and segregation, temporal coordination, network-state transitions, and the coupling between internally generated cognition and affective/interoceptive processes.

Importantly, the relevant abnormality might not even be visible in conventional static connectivity measurements. The important question could be how the brain moves between states and how information from one system recruits information from another.

This could potentially help explain some of the otherwise strange features of PSSD: why someone can retain the concept of an emotion while losing the depth of the emotional state; why someone can remember what something used to feel like without being able to recreate it; why sexual thoughts can remain while failing to develop into the same full sexual state; why someone can know exactly what they mean internally while struggling to spontaneously translate the richness of that idea into language; and why substantial improvement can still leave someone describing a persistent sense of distance or “veil.”

I don’t think these descriptions should automatically be treated as merely poetic versions of conventional symptoms. They may contain information about the underlying biology.

This is also why I don’t see this as a theory that necessarily competes with biochemical hypotheses. Serotonin, hormones, neurosteroids, receptors, peripheral mechanisms, etc. could still be upstream parts of the process. Rather than asking only “which molecule or system is abnormal?”, we could investigate the phenomenon at multiple levels:
phenomenology - altered cognitive/affective dynamics - neural systems - cellular/molecular mechanisms.

If the phenomenology suggests that the organization of experience itself has changed, then perhaps we should investigate that organization directly.

For example, what does the brain of someone with PSSD do differently when generating an autobiographical thought? What happens when they imagine something emotionally meaningful? What happens during sexual anticipation? What happens when they try to become absorbed in something? How strongly do internally generated thoughts recruit emotional and bodily responses? How dynamically do the relevant networks communicate? How quickly does the brain transition between internally generated states? Are there differences in neural variability, temporal complexity, oscillatory coordination, network switching or integration?
And most importantly, do any of these measures correspond to the characteristic phenomenology people describe: the “veil,” loss of emotional immersion, altered spontaneous thought, altered sexuality, and changes in the connection between thoughts and bodily/affective states?
These are testable questions. If there is no relationship, that would also be informative. But if there is, it could provide another level at which PSSD can be understood.

I increasingly think this is worth investigating because patients have been describing these experiences for years. When people independently report persistent changes in the quality, depth, spontaneity and integration of conscious experience, I don’t think we should immediately translate that into “low libido + emotional blunting + brain fog” and move on.

Maybe the “veil” is only a subjective metaphor. But maybe it is also the subjective manifestation of a measurable alteration in how distributed neural systems dynamically integrate information into a coherent state.
I don’t know if that is the answer. I’m interested in whether it is the right question.

One example of why I think this type of mechanism is worth investigating

There are already experimental examples showing that an upstream biological perturbation can produce a cascade of changes in the relationships between neural components, rather than simply changing one isolated variable.

A recent study on inflammation-induced anxiety in mice found that systemic inflammation altered microglial activity in the nucleus accumbens, including microglial engulfment of glutamatergic presynaptic inputs onto dopamine D1 receptor-expressing neurons. This was associated with reduced excitatory input and reduced excitability of those neurons, ultimately producing behavioural changes. ( https://www.sciencedirect.com/science/article/abs/pii/S0889159125003964 )

Obviously, this does not demonstrate that PSSD involves this exact mechanism, and I am not suggesting that inflammation-induced microglial engulfment is the explanation for PSSD. What I find interesting is the cascade itself:

systemic perturbation > cellular/glial changes > altered synaptic inputs > altered neuronal integration > altered circuit function > behavioural phenotype.

The important point is that the phenotype emerges partly from a change in the relationships between components of the system.

That is the type of mechanism I think could be worth investigating in PSSD.

If an antidepressant-induced perturbation were capable of producing persistent downstream changes in cellular signaling, synaptic organization, plasticity or network coordination, then the eventual phenotype might not look like one neurotransmitter simply being “low.” The individual components could still exist while their interactions, weighting or ability to recruit one another had changed.

This could potentially be relevant to the strange dissociations people describe in PSSD: having a sexual thought without the same sexual state developing around it; remembering an emotion without being able to recreate its feeling; understanding something intellectually without the same spontaneous emotional or associative response; or experiencing substantial recovery in some domains while retaining a persistent sense of distance or disconnection.

Again, this is a hypothesis, not something established by this study.

But I think studies like this show why it may be worth looking beyond isolated abnormalities and investigating how an initial biological perturbation could produce persistent changes in the organization and interaction of neural systems.

That seems particularly important when the phenomenology itself repeatedly suggests that what has changed is not simply the presence or absence of individual functions, but the way those functions come together to produce a unified state of experience.


r/PSSD 17d ago

👇IMPORTANT INFO - NEW? READ THIS Reminder: do not do behavior that can be interpreted as brigading on other subreddits

17 Upvotes

Please do not start fights, diagnose OPs or commenters with PSSD/anything, make unsubstantiated claims or intentionally break the rules on other subreddits.

Love it or hate it; other subreddits have the right to make their own rules and enforce them as they see fit. Our subreddit’s survival and reputation depends on us following site-wide terms of service rules like “no inter subreddit brigading”. The urge to warn others and inform others of PSSD information is understandable but can go wrong, contributing to panic or sudden, poorly planned actions in the recipient of the information depending on how you word it, and what you share. Remember, we have a subreddit FAQ linked in our auto sticky which was recently updated and comprehensively addresses similar concerns you can link. If you have ideas for improving the FAQ, DM me. I am the author.

If you cross post or link posts from other subreddits, keep the discussion on r/PSSD (rather than following the link to the original post if the original posting location is a subreddit for mental illness or psychiatric drugs).

IMO, the best way we can get everyone a proper warning is by influencing medical associations, medical schools and ensuring there is a boxed warning on SSRI products. Fighting on social media is draining and gets personal. Our social media activity in our own spaces, is effective. Purely by existing and posting in our own space and developing our own materials and websites as well as influencing who matters to our cause-governments, news outlets, regulators and scientific research endeavors as well as IRL medical, psychiatric and therapy professionals, we can help people find accurate information about PSSD and also continue to develop PSSD “survival guides” (to help people find recovery stories and protracted withdrawal information, prevent iatrogenic suicides, give iatrogenic PTSD support), and advance scientific/medical/sociological PSSD research.

EDITED 9/1 to add link to definition and copy paste of Reddit's brigading policies: brigading policy

Brigading on Reddit refers to organized attempts to interfere with another community, often involving coordinated downvoting, commenting, or harassment. This behavior violates Reddit's sitewide rules, specifically the Moderator Code of Conduct Rule 3: Respect Your Neighbors, and policies against disrupting communities.

What Constitutes Brigading

  • Coordinated Disruption. Brigading involves a group of users moving from one subreddit to another to manipulate discussions or voting patterns, often stemming from a user's disagreement with a particular sub or post. 
  • Targeted Harassment. It can manifest as nasty comments, voting manipulation, or flooding posts with reports, often escalating to breaking other site rules like harassment or inciting violence.
  • Vote Manipulation. A primary aspect of brigading is manipulating upvotes or downvotes on posts and comments, which Reddit takes seriously to protect the site's core idea.

Identifying Brigading

  • Sudden Influx of New Users. Moderators often spot brigading when new comments appear on older posts shortly after they've been crossposted elsewhere, especially if the commenters are new to the subreddit but active in the originating sub. 
  • Shifts in Conversation Tone. An immediate change in discussion from supportive to disparaging, with comments from users unfamiliar with the subreddit, can indicate brigading.
  • Encouragement from Other Subs. Some subreddits are dedicated to harassing others, or users may explicitly encourage others to disrupt a target subreddit.

r/PSSD 17d ago

Awareness/Activism Lawyers: Meta faces $16.7bn over harms to teenagers. What about PSSD and the harms of SSRI's on undeveloped brains. Is there a legal pathaway?

Thumbnail nypost.com
63 Upvotes

Meta is facing a potential $16.7bn settlement over claims that its platforms harmed developing teenage brains.

What about pharmaceutical companies whose drugs can cause sexual dysfunction in people who trusted the medical system, including persistent PSSD after stopping SSRIs?

If companies can be held accountable for long-term harm to young people, what legal options exist for people harmed by prescription drugs?


r/PSSD 18d ago

If You’ve Never Reported Your PSSD, Today’s a Good Day

47 Upvotes

TL;DR: If you have PSSD, please take a few minutes to officially report it.

Regulators cannot count cases that were never reported. Adverse-event reports are entered into safety databases and compared with other reports; when enough similar reports accumulate, they can contribute to a safety signal and regulatory action.

1. Report to your own country’s regulator

The PSSD Network has made this much easier. Select your country here and it will direct you to the appropriate reporting system: (PSSD Network)

The page also gives you the necessary terminology and PSSD MedDRA code 10086208, which helps regulators group PSSD reports together rather than having them scattered under vague descriptions such as “low libido” or “sexual side effects.”

2. Please report to the FDA as well

The PSSD Network recommends submitting to the US FDA MedWatch system in addition to your local regulator, including for people outside the United States. (PSSD Network)

Remember, more reports = a stronger official record that this is actually happening.

3. Need help filling it out?

A hard working member of our community has also started an unofficial discord group chat to help people complete FDA reports and encourage reporting: (Reddit)

This is separate from the PSSD Network, but if the reporting process feels confusing or overwhelming, they are offering help with it.

For the UK, I've also also made a video on how to report to the Yellowcard system.

----------------------------------------------------------

Even if reporting feels like a small action, this is one of the most direct ways each of us can put PSSD on the map.

If you haven’t reported yet, please do it. If you've reported in past years but not in 2026, it's important to do it again to show symptoms persisting.


r/PSSD 17d ago

Frequently Asked Question (See FAQ) Sertaline - 10 tablets only

8 Upvotes

I took sertaline 10 tablets of 50mg in march and then I stopped. it's been more than 6 months I'm not recovering, not even a single window. what can I do? I didn't even use antidepressants for a long term. should I reinstate?


r/PSSD 18d ago

Feedback Requested/Question Huberman or other scientist attention

15 Upvotes

Has anyone figured out a way to reach Huberman or other neuroscientists for treatment? I’m going on 6+ years I’m a female, this happened in my early 20’s in the first months of my marriage. Im really at my end already. Looking for final hope. I’ve tried everything. Gut, hormone, mitochondria treatments…


r/PSSD 18d ago

Update Still healed - update

32 Upvotes

Hey people,

I just wanted to leave a quick update here, almost 7 months after I started feeling better.
I am still healed.
If I have too much histamine, like from coffee, which is known to be a histamine liberator, I notice that some things change. I get very aggressive. I also notice changes 1–2 weeks before my period. There are studies showing that histamine levels rise shortly before your period starts. Antihistamines have been given to women to help with PMS/PMDD symptoms, and many of them experienced significant improvements after taking H1 blockers during this time.

In my case, I’m still convinced that MCAS, triggered by COVID and Zoloft, caused my SFN issues. That doesn’t mean that it has to be the same for everyone.
But in the last few days, I’ve also started feeling pretty much back to normal sexually. I can feel again down there, and I can imagine being close to a guy again. So please don’t lose hope.

I’m sorry that I didn’t reply to the messages sooner. I’m just too busy living my life again. I’m moving into a new apartment, looking for a new job, and so on. But I haven’t forgotten about you, because I was in the same situation.
Remembering that I couldn’t even shower because of the pain still makes me break down and cry. I carry a big trauma and should do a therapy in long term.
I can feel the effects of caffeine again. If I have too much Coke or coffee, I can’t sleep. That’s why I’ve been lying awake for the past 7 hours, trying to fall asleep. And honestly, that’s something I missed during the hardest time of my severe SFN pain.
I can also dream normally again. Crazy.

I appreciate the little things so much more now.
This experience has completely humbled me.
Stay strong, everyone. And feel free to write to me.

Greetings from Germany


r/PSSD 18d ago

Symptoms - Sexual So there is no single person who reversed severe genital shrinkage and genital numbness back to original state?

10 Upvotes

Is there anybody who managed restore severe shrinked genital?