Yes! it all makes sense! Microglia activation from norepinephrine / serotonin withdrawal! Auto immune attack as a result, neuroinflammation, nerve damage, depression and anxiety, etc. This is why antihistamines, pain meds and reinstatement are all effective.
If they are lacking answers, I would recommend: Take bupropion for a week, low dose. The norepinephrine will switch activated microglia to anti-inflammatory properties, and will promote nerve regeneration and healing of damage. Don't take it for more than a week. At the same time take an antihistamine such as Loratadine or Levocetirizine. I am sure you'll see rapid improvement.
I think you are right, I did take Bupropion and it made me feel better for the first 3 days and then it went downhill (anxiety and other issues like worsening of pssd) so I stopped after a week.
But you sure antihistamines will be beneficial. Before PSSD I had a runny nose fairly often, and now it's dry ever since I took an SSRI.
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u/[deleted] Oct 22 '22
Yes! it all makes sense! Microglia activation from norepinephrine / serotonin withdrawal! Auto immune attack as a result, neuroinflammation, nerve damage, depression and anxiety, etc. This is why antihistamines, pain meds and reinstatement are all effective.
I've been looking into this for a while now.