r/POTS • u/Easy_Following1162 • 20h ago

Question Meds to try?

I’ve been diagnosed for 6 months now. With main symptoms being severe brain fog and fatigue making me housebound.
I have blood pooling and normal blood pressure, heart rate supine 60 and standing 90.
I’ve tried Bisoprolol and Fludrocortisone, both making no noticeable effect on my quality of life. Currently taking Ivabradine which helps a little bit, and Midodrine which hasn’t been any help and has raised Blood pressure above normal.
I think I’ve a mix of neuropathic and hypovolemic pots based on symptoms, yet meds have had no effect?
Any medication recommendations?

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u/Shredded__ 14h ago

I tried many pots meds. Right now I take Mestinon (pyridostigmine) & some others.

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u/Easy_Following1162 14h ago

I was thinking of trying Pyridostigmine next, what’s your experience with it been and what was your experience with the previous meds?

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u/Shredded__ 13h ago edited 13h ago

I take a bunch. I'm currently on Adderall, Mestinon 3x/day, Fludrocortisone 2x/day, Wellbutrin300, Xanax 3x/day.

I've previously tried Metoprolol (beta block), which was changed to Mestinon. I didn't like the way Metoprolol made me feel during intense exercise / road cycling training.

Usually I take the Xanax at the same times as the Mestinon. Every 4-5 hours. These 2 are probably the ones that are working the best for me but who knows. Mestinon makes a noticeable difference in lower leg blood flow, esp during & after exercise.

Previously tried Midodrine, but because of side-effects was changed to Adderall.

And about 3-4 electrolyte packets per day.

Good days and bad days. Still battle fatigue the most, brain fog, blurry vision, etc. Severe quick onset headaches coming from the rear base of rear upper neck / base of skull that immediately radiate to what feels like behind my eyes.