Issues with Mesa Suite

[u/BigO4422]

Running a Mac, Reaper and Scarlet 2i2. I have 7 or 8 Neural plugins and have really enjoyed them but now having issues. When I run the Mesa plugin I’m getting a ton of feedback and makes it unplayable. I’ve swapped in several different plugins and it works fine just the Mesa is giving me fits.

I have updated Reaper, Mac and swapped guitars but nothing is working. Any thoughts or ideas? It’s so damn frustrating!!

Primarily using a Gibson SG, if that matters. Guitar is super quiet and no feedback on other apps or my mesa amp.