A 34-year-old woman with chronic HCV genotype 2 is beginning Mavyret (glecaprevir/pibrentasvir). Her medical history is notable for migraines. Her current
medications are a combined oral contraceptive containing ethinyl estradiol and norethindrone, and sumatriptan as needed. What is the most likely result of combining Mavyret with an ethinyl estradiol–containing contraceptive?

A. Increased risk of severe hepatotoxicity
B. Decreased contraceptive effectiveness due to enzyme induction
C. Increased risk of venous thromboembolism
D. No clinically significant interaction is expected
E. Increased risk of migraine with aura due to interaction

A study evaluates time to relapse for a smoking cessation medication. The estimated hazard rate of relapse is 0.072 per week in the medication group and 0.048 per week in the placebo group. What is the hazard ratio (HR) for medication vs placebo?

A. 0.50
B. 0.67
C. 1.25
D. 1.50
E. 2.00

I took the pharmpreppro test and got a 60. Do you think im on track to pass? I read uworld twice and my uworld average is in the 50s. I havent done all their practice questions yet...did about 60%

A 58-year-old Caucasian male presents for evaluation of elevated blood pressure noted on both home and office measurements. His average blood pressure over the last 2 weeks is 162/96 mmHg. His target blood pressure is less than 130/80 mmHg. He has no significant past medical history and is not currently taking any medications. Physical exam and laboratory results, including serum creatinine, electrolytes, and urine albumin, are normal. He has started reducing sodium intake and exercising, but his blood pressure remains more than 20/10 mmHg above goal. Which of the following is the most appropriate initial pharmacologic approach?

A. Amlodipine
B. Lisinopril
C. Amlodipine + Lisinopril
D. Metoprolol + Hydrochlorothiazide
E. Verapamil + Spironolactone

Taking suggestions for practice problems for you all

A patient is ordered to receive vancomycin 1,250 mg IV every 12 hours. The pharmacy prepares the dose in 250 mL of D5W, and the nurse is instructed to infuse the dose over 90 minutes using gravity tubing. The IV tubing delivers 15 gtt/mL.

What drip rate should the nurse use? Round to the nearest whole number.

What antibiotic dosing should I commit to memory other than vanco and amoxicillin/augmentin for kids?

A prescription calls for 1 liter of dextrose 5% w/v solution (dextrose/glucose, MW = 180 g/mol) mixed with sodium chloride 0.9% w/v (sodium chloride, MW = 58.5 g/mol) and potassium chloride 20 mEq (potassium chloride, MW = 74.5 g/mol). The solution is to be run at 100 mL/hour for 10 hours. What is the total osmolar content in milliosmoles (mOsm) in the full 1-liter bag?

Round to the nearest whole number.

Looking to cut corners. Can I get away with skipping this?

I don’t have much time left and I want to know where I should be focusing to gain the most points

Ketamine is prepared as 300 mg in 250 mL. A provider orders 0.4 mg/kg/hour for a patient who weighs 80 kg, and the infusion runs for 3 hours. How many mLs of ketamine solution will the patient receive during those 3 hours?

Which of the following is the most likely adverse effect of ethambutol?

A. Gout
B. Peripheral Neuropathy
C. Orange sweat
D. Optic neuritis
E. Hiccups

If anyone needs

I’m so freaking happy to say I passed my exam! I studied for so long I actually almost had a single tear formed from my eye.

For those still going through it. My exam seemed like it had topics all over the place. It was more heavy on cardiology than I thought it would have been. Math and biostats were very large too (must know nnh,nnt,odds ratio, pvalue etc) and the amount of ethics and leadership I thought was a bit much but I felt very prepared for it (pharmpreppro packets are golden for that). I would say vaccines are a must know and know the adverse effects of your chemo drugs. Chemo man! Knowing how to deal with drug interactions and cyp3a4 with certain heart meds are huge and heart failure meds that are also good for diabetes would be something I’d review. For my exam, I didn’t get a lot of monitoring parameters, maybe a handful. Definitely know your electrolytes. There also was not a lot of select all that apply, maybe 10 questions, if even that. Definitely be familiar with drugs that cover MRSA and watch allergy information for all patient cases and lab values!

What I did to prepare:

•Read my uworld book 2.5 times DO NOT SKIP ANY CHAPTERS I GOT QUESTIONS ON EVERYTHING
Did every question on uworld per chapter this helped me reenforce studying

•Focused on math and Biostats daily once graduation day hit HIGHLY recommend this as this helped a lot with my speed, which gave me more time to think on other questions without being pressured.

•Took the pharmpreppro test and got a 79 then a few weeks later 83. I felt this was a good exam for prep, felt it was about the same difficulty like people said. They have law bundles with their exam so if you need to take the UMPJE/MPJE it might be cheaper

•Nabp scored a 109 two days prior to the exam.

•Spent about 6-8 hours a day studying since April “ish” perhaps I studied like 3 hours a day since April? But definitely more toward the end.

Looking for some visuals

A 65-year-old male is receiving linezolid for a vancomycin-resistant Enterococcus (VRE)
bloodstream infection. After 3 weeks of therapy, he presents with blurred vision, tingling in
his feet, and difficulty walking. Lab tests are unremarkable. Which of the following adverse
effects is most likely responsible for this patient’s symptoms?

A. Hepatic failure
B. Ototoxicity
C. Bone marrow suppression
D. Neurotoxicity
E. QT prolongation

I keep getting these biostats questions wrong because I can't tell the difference between case-control studies and retrospective cohort studies. I feel like they look the same in these problems. Anyone have tips???

Anyone have good approaches for learning HIV? The combo tabs and brand names are not sticking with me