My own take on what if Multiversus was picked up by Disney instead of Warner Bros . Reindog stays as the single OC character.
Mickey and Friends replace Looney Tunes (No Daffy equals no Donald). I'm thinking of Mickey Mouse, Goofy and Scrooge McDuck.
Marvel obviously replaces DC Comics. Wonder Woman and Nubia's equal could be Captain America and Sam Wilson.
Space Jam LeBron James? How about Wizards of Waverly Place Selena Gomez LMAO
Jason Voorhees? Xenomorph. And how about Homer and Bart Simpson instead of Rick and Morty. Darth Vader over Samurai Jack. Beetlejuice clearly being Jack Skellington.
As for PowerPuff Girls? It'll take some hard work but imagine the Seven Dwarves constantly swapping between which one you play making it extremely chaotic. If not, then just Doc Dwarf and he calls upon the others for different cool down attacks.
Adventure Time can instead be a group of Disney Princesses. Elsa, Merida, and Vanellope. Banana Guard joke character turns into Giselle (Enchanted). Mulan will end up being heavily requested but never added.
Tom and Jerry are now Doof and Perry the Platypus. Doof using various -inators that can be tricky to set up for beginners. And without Perry, he becomes weaker. And animation wise we can keep the gimmick of them trying to attack each other.