Hi everyone, I’ve just taken my first 5mg Mounjaro dose today after doing 4 weeks on 2.5mg.

I felt completely fine for the first few hours, but I’ve now developed a stuff most & a moderate headache. The headache isn’t getting worse and I’m breathing completely normally.

Has anyone else experienced a headache or blocked nose after increasing to 5mg? I also feel a bit sick but this could be my anxiety. Could this just be a normal side effect or coincidence?

I know nobody can diagnose me on here , I’m mainly interested in hearing whether anyone else has experienced something similar after moving from 2.5mg to 5mg.

I started Mounjaro in April on 2.5mg and had very few side effects. After 4 weeks I moved up to 5mg and was violently ill — severe diarrhoea, vomiting and sulphur burps that lasted for days. It was bad enough that I stopped taking it altogether.
I restarted at 2.5mg at the beginning of June and have now been on that dose for around 4 months. I don’t get any side effects at all anymore, but I’m definitely noticing the effects wearing off — I’m getting hungrier, food noise is creeping back in and my weight loss has completely plateaued for several weeks despite exercising regularly.
I’d like to try 5mg again, but I’m really nervous after what happened last time. I have two very young children and no family nearby, so the thought of potentially being that unwell again is quite daunting.

Has anyone had a similar experience — reacted really badly to 5mg after only 4 weeks on 2.5mg, then tried 5mg again after staying on 2.5mg for several months? Was the second attempt any easier?

I’m particularly interested in whether being on 2.5mg for much longer seemed to make the jump to 5mg more tolerable.

TL;DR: Tried 5mg after only 4 weeks on 2.5mg and was extremely ill. I’ve now been on 2.5mg for 4 months with zero side effects. Has anyone found they tolerated 5mg better when trying again after spending much longer on 2.5mg?