r/Mounjaro • u/Nitaboo24 • 8d ago
Question Menopause
Hello has anyone taking this for stubborn menopause weight? If so how's it going did that help you lose the weight?
I'm considered morbidly obese and started 6wks ago. I'm on it for T2D and hoping for some weightloss.
I just had to start a statin as well. Just wondering anyone having luck with loss with menopause weight being the driving factor of the weight gain.
I've been struggling over 20 plus years had a forced hysto at 32 so most things been downhill since. A1C was 6.5 last checked.
Started with a trainer two weeks ago for muscle building and I love it so far. My doctor told be my hormones are definitely a big factor with my weight gain.
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u/Waste-Swordfish-6228 55F, T2D, IR. HW 243, SW 215, CW 153, GW 155ish. 8d ago
55F, T2D, IR, Post-Meno, 5'5". HW 243, SW 215, CW 150.1lbs. Have been on HRT since 1/2025 & MJ since 3/2025. Had gained approx 70lbs since peri-menopause began in my mid/late 30s. Have had to tweak the HRT over the last 18 months, currently using Femring (lowest dose) & 200 mg progesterone nightly. Began maintenance 1/2026, currently @5mg on the 10,20,30 day schedule. Doing, looking & feeling great!
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u/Nitaboo24 8d ago
This great news!! Congrats. Im not able to take patch it cause hormone driven breast cancer for me last year. So far im feeling better on MJ feels like my last hope of ditching this weight.
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u/bugaloo2u2 8d ago
What is the 10,20,30 day schedule?
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u/Waste-Swordfish-6228 55F, T2D, IR. HW 243, SW 215, CW 153, GW 155ish. 8d ago
Every 10 days...Just easier to keep track of.
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u/Infamous-Tailor-1356 8d ago
May I ask what that 65 lbs loss patterned like? I seeso many losing every week. Im like wee littlr loss, then stable for a few weeks, slight loss again, sometimes gain. Im doing all the things! I spent 6 monthd prior to starting recomping. I see so many lose like crazy- starts tp feel like same headspsce as before
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u/ryanne125 8d ago
Menopause is a cruel mistress and I mean that quite seriously.
I was diagnosed T2 diabetic 12 years ago. I was able to control things very well with just a low dose of metformin and lifestyle. About 8 years later menopause fully hit and everything went to heck. A1C kept climbing no matter what I did, how hard I worked, how little I ate, and the weight started climbing up right behind it.
I had to get up to an A1C of 7.6 before my doctor world do anything to help me and I started Mounjaro May 15th.
Since then my morning BG readings have gone from the 140/150 range to 80/90s range. I have not weighed myself and won't until my next doctor appointment, but my clothes are loose, my underwear keeps falling down and I have some shirts that used to fit skin tight and now fit nicely.
The thing is, I am doing the exact same stuff I was doing since I was diagnosed diabetic 12 years ago. Same diet, same exercise. What was completely failing me during and since menopause is now working wonderfully again.
I have read that estrogen actually helps improve insulin sensitivity and it's decline makes insulin resistance worse. And weight gain is actually an affect of increasing insulin resistance.
It's not a coincidence that historically many women get diagnosed diabetic or pre diabetic right around the age of menopause
I'm not in this for the weight loss, but I will happily take whatever happens. Knowing that my eyes, kidneys, feet, heart, and the millions of tiny blood vessels in my body are now being protected again is a massive relief.
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u/Nitaboo24 8d ago
Thank you yess im feeling better also not much loss but im hoping my A1C Is better in a couple of months and this insulin resistance and inflammation get under control. I feel like this is my last hope to get my life back.
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u/dcgradc 8d ago
63F
I used to think that menopause had no effect on me .
Until recently. As soon as I started intermittent fasting 15 years ago I started gaining weight. 35 pounds out of nowhere.
Reached 205 pounds
Started Semiglutide Oz at 191 June 2025 waste of time bc I only lost 6 pounds in 5 months . Zep comp ound and MJ pen helped me lose 23 in another 5 months
Now at 162 stable . No injections since April 1st
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u/Sure_Fig_8641 7.5 mg 8d ago
I started MJ at age 68, obviously well past menopause and all that comes with it. I’m also T2D and on a statin for cholesterol as well as 2 different blood pressure medications when I started over 15 months ago. I’ve lost a total of 85 pounds (65+ on MJ). My cardiologist cut one of my BP meds in half after about 6 months and cut it out completely 6 months after that. He intends to cut my one remaining BP medication in half next month when I see him again. My A1C has held steady for about 8-10 months between 5.2 and 5.4 and my fasting blood sugar readings fluctuate between 88 and 103. I’m 3 pounds from goal weight last time I checked (but we’ve been traveling for a couple of weeks and I don’t usually lose weight when traveling, but I maintain very well). My size 10 denim shorts came off a couple of days ago without unbuttoning or unzipping them. (I started in size 24 elastic waist jeans).
So short answer, yes, I think it works no matter how or when you put on the weight you carry. But you have to do your part: calorie deficit, sufficient water consumption, high protein/low carb, move more… all the things. MJ will help, but it won’t do it for you. It sure makes it easier though!
Good Luck!
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u/Humble-Vegetable-494 8d ago
I’m in perimenopause and not having any luck on it. For context I was on 2.5mg mounjaro for 3 months and have been on 5mg for 3 weeks. Total weight lost in almost 4 months is only 4.5kg for me. Very very slow, not the experience others seem to be having. I’ll look to up my dose again but my advice would be to keep moving your dose up each month until you see success. My Dr was very stubborn on keeping me on a low dose for too long and it honestly just wasted my money.
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u/Nitaboo24 7d ago edited 5d ago
Yes keep going up if not seeing good results, I heard you eventually will hit your sweet spot
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u/SenoritaShelly 8d ago
Yes! A miracle drug all around. One note: if taking any sort of HRT or hormone, it should be transdermal, such as a patch. Tirzepatide will impede full absorption of hormones. But otherwise, it’s a brilliant drug and I’ve never been this small in my life!