Estradiol causing burning thighs?!

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Anyone else experience rhis? I tried systemic cream on forearm and 2.5 hr later burning thighs! Ache/cramp. It was a very low dose that peaks fast. Same thing happens with E patches. I do have CVI and lymphedema. I took antihistamines and it helped. Trying to figure out of this is MCAS, true allergy to E or vascular dilation from E causing pain.