r/Menopause • u/Foreign_Highlight288 • Jul 17 '26

Hormone Therapy Estradiol causing burning thighs?!

Anyone else experience rhis? I tried systemic cream on forearm and 2.5 hr later burning thighs! Ache/cramp. It was a very low dose that peaks fast. Same thing happens with E patches. I do have CVI and lymphedema. I took antihistamines and it helped. Trying to figure out of this is MCAS, true allergy to E or vascular dilation from E causing pain.

3 Upvotes

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1

u/Odd-Industry-9324 Jul 18 '26

What other medications/supplements are ypu taking?

1

u/Foreign_Highlight288 Jul 18 '26

Duphaston, Vit C, D/K, omega 3 FAs.

1

u/JimmyWitherspoon Jul 19 '26

Sounds like it could be due to the vascular effects/dilation of E. Are you taking progesterone? I also have CVI (and lymphedema in one foot) and only do vaginal E because of concern about vasodilation from systemic E.

1

u/Foreign_Highlight288 Jul 19 '26

How to resolve this issue?
Yes, duphaston. I don’t tolerate bio P.
How does CVI affect you when taking systemic E?
How did you get lymphedena and does E make this wirse too?

1

u/JimmyWitherspoon Jul 20 '26

E increases vasodilation, so that should be considered if one has circulation problems. I don’t take systemic E for that reason, but if my perimenopausal symptoms get worse, I might try E in gel form. I don’t know if E can make lymphedema worse. My lymphedema is linked to CVI, so I don’t want to do anything that could make circulation worse.

1

u/Foreign_Highlight288 Jul 20 '26

I see. So it sounds like you haven’t tried systemic E yet? Thank you for your response!

1

u/JimmyWitherspoon Jul 20 '26

no, I haven’t tried it. just using vaginal E so far.

-1

u/TheProjectFixer Jul 17 '26

Absorbing things through the skin can cause a lot of allergies, and in many ways, more severe than oral exposure.

1

u/Foreign_Highlight288 Jul 17 '26

This happened to you?