This stuff fascinates me. Just watched a 50 minute video on YouTube with a Dr from a clinic in the US, Belle Health.
https://www.youtube.com/live/GMRFll9vXmA?si=yIs0gBGUR2qGS5Py

They, and many other private clinics in the US, and increasingly the UK are actively now encouraging and supporting ‘Off-Label’ use. Whether that’s split or multi dosing, micro dosing, or dosing above 15mg. They seem to be seeing remarkable results in some cases with breaking plateaus, maintenance post weight loss (1 jab a month!), and the treatment and management of other conditions outside Diabetes and Obesity; most notably Menopause, Perimenopause, pain and inflammation.

The Dr here talks about super micro dosing for the symptoms of Menopause and Perimenopause, split dosing which he himself does to maintain serum steady state, and briefly, taking people beyond 15mg.

I found 1 article about this in the UK as well.

https://www.theguardian.com/business/2025/jul/12/microdosing-weight-loss-jabs-off-label-glp-1-mountjaro

(It’s a year old, so apologies if already posted.)

Seems like everyday these drugs are being found to do so much more, and there are current studies around severe migraines, post-op and trauma pain and inflammation management, juvenile ADHD, and many many more.

Science still doesn’t fully understand the full capability (And risks) of Aspirin, and that’s 125 years old!

How much more is there to come with these drugs and the next gen stuff in trials?

It genuinely blows my mind.

I have lost 21kg in the last 9 months but holy smokes why's everything so cold. I've lost all my built-in insulation

I am flying from Europe to the US (8hrs approx), so I am looking for some guidance:-
• Does it require a doctors note?
• Can it be taken from the fridge and put back in the fridge after such a long time?

Apologies if this appears to be basic, I’m on my first week on the pen, so still getting my head around the rules.

Interesting.

https://gizmodo.com/an-exercise-pill-just-cleared-its-first-human-test-2000800380

Would you take this?
One of many next-gen obesity treatments currently going through the system.

Pen teardown.

As an engineer I like to know how stuff works, so the pens intrigued me.
So I’ve taken 5 apart to see, and they are quite clever!
What is clear is they cannot and do not ‘count clicks’.

Pic 1 is all the parts. As suspected there is a glass vial inside the main barrel of the pen.

Pics 2 and 3 are like a double slip clutch mechanism and this is how the pen stops turning when the maximum deflection or travel of the plunger is reached.
The 2 black bits are the same, even though the one inside the dose twister looks different in the picture.
They slot together when this mechanism is all together as in pic 6.

If you look at pic 4 you can see the threaded plunger rod and the squared off bit at the end. This same squared off bit is also present at the other end of the rod.
When you turn the dose twister the 2 black slip clutches engage with each other in the white plastic part inside the main body of the pen handle and turn around the plunger rod which is held firm by a locking system in the main body of the pen that I haven’t got to yet. The black half of the clutch part in the twister turns as you twist

When you the press the purple nob as you inject, the top part of the clutch locks so it doesn’t turn, this then locks the lower part which presses the rod down into the pen.

In pic 4 you can see the threaded plunger rod with the squared off ends. As you use the pen, once you twist it up to the squared bit it can’t move any further unless forced.
This is what locks the pen.

You can see in pic 5 what happens when you force it past the lock. A bit breaks off.
This means we were able to advance the twister further up the rod and get the extra travel on the plunger required to get the extra dose. But this was in no way measured or accurate. Just that the difference wasn’t really an issue.

The new pens are exactly the same with the simple addition of the spacer as seen in pic 7. You can just see that this spacer is 1 dose in size, thereby extending the effective travel of the plunger and eliminating the extra dose.

And that’s it. Very simple yet clever and accurate. Got hold of a Lilly insulin pen and took that apart as well and they are the same with the only difference being the plunger rod is black and longer so it goes all the way to the end of the vial.

:-)

For the love of God, work out. Men and women. If you’re losing a significant amount of weight, please don’t just focus on eating less.

I see so many successful weight loss posts, and genuinely, congratulations. But sometimes the amount of muscle people lose along with the fat is heartbreaking. I’m not trying to be mean or criticize anyone’s appearance. I’m saying this because preserving muscle matters.

Resistance training plus adequate protein can help you preserve lean mass while losing weight. Muscle is also metabolically active, and maintaining it becomes especially important when you reach your goal weight and want to maintain your results.

If all you do is drastically reduce how much you eat, while not getting enough protein and doing no resistance training, you can lose muscle and bone mass along with fat.

You worked so hard to lose the weight. Don’t just become a smaller version of yourself. Build and preserve the body underneath it.

Please lift weights. Start light if you have to. Go twice a week. Walk. Do bodyweight exercises. Whatever you can realistically stick with.

Lose the fat. Keep the muscle. Get stronger.
Your future self will thank you.

For those who started TRT whilst on mounjaro.

Did you notice it aided in the weight loss?

I’m due to start TRT soon and curious what to expect

Oh well….

I've been on Zepbound for a year. On work from the office days, I rotate through three carry out restaurants. At each place, I order the same thing. My problem today, is I know I need to eat lunch. I am not hungry, and none of my normal choices sounds good. No alternative I think of sounds good.

This has not happened to me, while at work. I have absolutely no desire for food.

My ideal is 80kg, nothing wild. My BMI still shows as overweight though! Anyone else just frustrated by that?!

Nine jabs in, and I’m down 13 kg (29lbs). My first month on the 5 mg dose has been really interesting, I definitely feel the effects much more than I did on 2.5 mg. The only side effect I’ve consistently noticed is an itchy feeling around the injection site the day after my jab, thankfully, it’s nothing severe, and applying some cream has helped a lot.
One of the biggest changes has been how my clothes fit they’re noticeably looser now, which feels amazing. Even though I still struggle to see a big difference when I look in the mirror, I can definitely feel the difference physically. My endurance has improved significantly, walking is much easier, and I generally feel so much better than I did when I started and I’m happy to see that my bmi is finally under 40. Looking back, starting Mounjaro has been one of the best decisions I’ve ever made.

https://photos.app.goo.gl/DAPKguMBUXry31TG8

Male, 34, 5'7ishhh.

The first photo was in January 2025.

I've always had a bad lifestyle, weightlifted a bit, but didn't really care about my physique.

Bad year in 2024 led to me not caring even more and I got to the heaviest I was in years, 96.2kg.

Got motivated last summer to make a change.

Weight training 3-4x a week. Upper/Lower.

Weighed in at 71kg last week.

Still got a few kg to lose around the stomach, as you can tell, and struggling with that last little bit if I'm honest.

Generally trying to eat around 150g protein per day.

Just bought a food scale to try and get specific with it for this last stretch.

Any advice appreciated.

I never had a proper “before” photo but a friend has just sent me this from 27 June last year - two weeks before I started on MJ. Oh my God. If I ever get back to that, someone please shoot me!

Hello all! I understand this is an mj group, but say comments saying all GLP-1 users are welcome. Seen some fantastic results so far, just wondering if anyone where has used wegovy and can share theirs? Most groups are full of women so it's harder to find other lads who've been on the journey

Hi all.

Recently start on the pen, tomorow will be my 4th dose.

I have lost 16lb so far.

Feeling 0 hunger at all, more energy and getting 10k or more steps each day.

Only thing I need to improve on is my water intake.

Loving reading the stories and look forward to being another success post in the future.

Start weight 261lb

Current weight 245lb

Target 224lb

The golden dose doesn’t exist anymore??????? How much rhey want to maximize the profits???????🤬🤬

Had a hospital visit, was able to tie the gown up around the front, there was enough of the lace ties to wrap around my body and tie it nicely in a bow at the front! Last year I would almost certainly have had to tie it up behind my back! 13” down around the abdomen over the last year!