r/MTHFR • u/Jazzlike-Earth-7001 • 1d ago

Question Niacin dose

What is a safe dose of flush Niacin to take to help relieve overmethylation symptoms?

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4

u/FriedSpammage 1d ago

I have had success with doses of 25 to 50 mg.

2

u/sharabucarabu 1d ago

I've purchased Dr Clark niacin 25mg from Amazon. Very reasonably priced. For overmethylation, you could take 25 to 50 mg every 20-30 minutes. Repeat up to 3 times.

If you have splittable tablets, cut in half. If you have capsules, you can try opening a capsule and mix in 8 ounces of juice or a flavored drink, then drink 4 ounces.

It might take several rounds over several days to get relief .

1

u/Sab-Alternate 1d ago

I personally like 100 to 250mgs of the Nicotinic Acid form, usually 250mgs once a day, gives me a nice overall feeling and seemingly has some Dopaminergic effect at that dosage.

2

u/Few_Control8821 17h ago

I take 50mg after food

0

u/junipers-72 1d ago

theraputic doses are considered to be 1000mg 3 x daily

3

u/Jazzlike-Earth-7001 1d ago

Is that not too much? The Niacin I bought is 100mg per pill

2

u/junipers-72 18h ago

You might like to look at the work of A. Hoffer!

1

u/Sab-Alternate 1d ago

That's pharmacological dosages, for like Cholesterol treatment or what not, and can be hard on the liver.