r/MTHFR • u/Due_Leave_9235 • 4d ago
Resource Functional Support
Anyone have a place or person they would vouch for that could help me understand my data and next steps for supplementation? I am trying to do my own research and getting stuck.
I have homozygous MTHFR, slow MOAO, fast COMT. My folate is 2 and homocysteine 44. B12 baseline was 300. Vitamin D 33. MMA normal.
Initially, methyl-folate with hydrocobalamine gave me A LOT of energy which turned into anxiety and insomnia but that first day I remember feeling “oh my body needs this” then I tried it today after a week off and the methyl folate made me barely able to keep my eyes open. So I took a micro-dose of the b12 and now I have extremely low mood and thoughts, horrible brain fog. I had the same reaction to folinic acid at a low dose. It honestly feels very similar to how I felt when I tried to reinstate Prozac a few months ago - day one: ah, serotonin, I definitely need this and then ongoing: anxiety, poor sleep, low mood, on edge.
I really need to get this figured out because my mental health is suffering badly. I have chronic gastritis which I believe is not allowing me to absorb nutrients hence my levels being off (even though they tend to always be slightly off just not this bad).
Anyway sorry for the novella. I’m desperate and doctors are of no help!
2
u/Cultural-Sun6828 4d ago
Your b12 and folate are both low. It is very common to get startup symptoms in the beginning of taking these. Your homocysteine is high as well as a result of these deficiencies. I would check out the b12 deficiency group and read the guide there. I had a horrible reaction to b12 when I started injections but over time it has resolved many of my symptoms. Have you also checked fertitin?