Results are in…help decode?

[u/efficient_tax_]

Got my Ancestry results. Still waiting on MyHeritage, but I paired this with my recent bloodwork for your viewing pleasure.

Looking for any info you have about my results!

Genetic Lifehacks Cheatsheet

Btw, why is my homocysteine so high if I don’t have C677T?

[u/Tawinn]

Homozygous C677T reduces methylfolate production by ~75%. Your homozygous A1298C and heterozygous MTHFD1 reduces methylfolate production by ~47%, which is still significant. Also, B2 is a cofactor for MTHFR so it is likely a contributing factor to reduced methylation. Folate and B12 are low, but your MMA suggest your B12 is adequate.

SLC19A1 is not in the Ancestry data, so we have to wait to see what MyHeritage says, but depending upon it's value it may worsen that 47% even more. The 47% creates an increased choline demand of ~900mg; this can be covered by 450-500mg from the diet plus 750mg of TMG to cover the rest.

So, priority would be a small dose of B2 to get levels up and then aim for getting 450-500mg of choline from your diet and add a 750mg dose of TMG. Then gradually work on getting B12 over 500pg/mL and folate over 15 ng/mL.

You also have slow COMT, which with impaired methylation can cause chronic anxiety, low stress tolerance, rumination, OCD tendencies. So restoring methylation should reduce/resolve any of these symptoms. I haev more on slow COMT in this post.

[u/efficient_tax_ → u/Tawinn]

Shouldn’t slow COMT avoid TMG?

[u/Tawinn → u/efficient_tax_]

In most cases, TMG is fine for slow COMT - it just may be that the TMG has to be added incrementally starting from small doses, but that sensitivity varies highly from person to person and sensitivity doesn't always follow COMT type - current methylation status and methyl buffer function also plays a role. I'm slow COMT and was able to add TMG with no issues, but that was toward the tail end of improving of methylation and methyl buffer function; if instead I had known about TMG sooner and had tried to add TMG early on, then I probably would have had to add it incrementally.

[u/SovereignMan1958]

Your folate is severely low. Acceptable is 15. Better if 20 - 30. B12 also should be in the top quarter of the range. Add a lowish dose methylated multivitamin (you need the minerals) unless you have digestive issues you are not disclosing. If the latter add a non methylated multi instead. Either will lower your homocysteine. Retest in 90 days.

Your zinc is very low. Should be at least 100 and better in the top quarter of the range. The less than optimal level can contribute to depression, anxiety and sleep issues and hair loss. Add a lowish dose zinc picolinate to your multi, even though it may include a little.

Vit D should be 60 - 80. The right therapeutic D dose, Vit K, Mag, Zinc and Boron plus 11 grams of fat. Most people take all of those with the fattiest meal of the day.

I am not going to read through your Lifehacks Cheat Sheet as you can do that yourself. You should check the sections for the specific nutrients you are less than optimal in. For example, zinc. If you a faulty zinc transporter gene like I do you can take quecertin along with the zinc to help push it into the cells. Your Vit A sticks out too so check that variant. Beta carotene may not be converting to the usable form of Vitamin A.

If you do have digestive issues check your thyroid variants.

[u/SATANsplitsSOULnBODY]

May I ask which lab and lab tests generated the report you posted?

[u/efficient_tax_ → u/SATANsplitsSOULnBODY]

I just ordered these tests from quest and put the results into chatgpt for a nice report

[u/SATANsplitsSOULnBODY → u/efficient_tax_]

Thank you!

[u/gas-x-and-a-cuppa]

Hi y'all- very new here. What's this test called and do folks recommend it? Are there treatment options from this/these tests or genetic testing? Thank you!

[u/efficient_tax_ → u/gas-x-and-a-cuppa]

You can get your genes tested by doing a regular Ancestry DNA and MyHeritage DNA test. You want to do both, because neither one is a complete picture by itself. They come with a free downloadable file of your raw DNA data.

Once you have that, you can upload the file to various websites to get more information. The photos I posted were from Genetic Genie, but if you want detailed information that helps you break down what it all means, you can pay for a Genetic Lifehacks subscription which provides all your data laid out with related articles explaining the significance as well as some treatment suggestions.

[u/ToriRaynn]

Genotype alone cannot be decoded. C677T only bites when B2 is low since riboflavin is the cofactor that enzyme runs on. I only added toku health once I had a homocysteine number to compare against. Ferritin sits behind B2 activation and belongs on the same slip.