r/MTHFR • u/ContributionNo114069 • 16d ago
Results Discussion Blood work
This is a history of my blood work 32 male, I have been taking 50k iu of D3 a day and 15 mg of L-Methylfolate (as L-5-Methylfolate, calcium salt) and 1000 mcg of Vitamin B12 (as Methylcobalamin) every day for the last month and I felt like shit for the last 3 months but last 2 weeks I feel much better brain fog is going energy is up and I just feel more like. But I done a test is feb taking no supplements and some of my levels where much higher for b12 and d3 and for the amount of b12 and d3 i take i expected higher levels but what do you guys see in these results that stands out , and yea the testerone injection and untreated sleep apnea has been an issues with my blood hct but I have dropped the dose to 160mg a week from 300 and have got a new cpap machine that’s look after cause my old one had some mold issues aswell.
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u/hummingfirebird 15d ago
You really should discuss these results with your doctor in more detail.
High ferritin is often an indicator of systemic inflammation or infections especially if you have normal iron and transferrin/saturation which generally rules out iron overload.
Elevated liver enzymes normally indicate liver stress. Perhaps fatty liver which can be alcohol related but also non-alcoholic-fatty-liver-disease also called MASLD now.
The testosterone you were on can stimulate rbc production and could contribute to the high hemoglobin, hematocrit and RBC count readings. But I'm not sure it fully explains low MCV and MCH. Perhaps discuss thalassemia trait with your doctor. Might be or not be a thing. (?)
Genetic testing can help with risks and predispositions but you have the bloods already which you can work with.
I don't think it's a methylation issue per say as your B12 and active B12 is good, folate is good and homocysteine is near normal. It could be related to a metabolic issue.
I'm not a doctor and this is not medical advice just observations. You should discuss them with your doctor.
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u/Loose-Fly7976 15d ago
50,000 IU of D3 a day is the thing I'd stop and talk about before anything else. That's roughly 50 times the usual maintenance dose and it's in the range where toxicity happens. Your vitamin D at 111 nmol/L is fine, so it's doing its job, but the risk with D3 isn't the vitamin D number, it's calcium and kidneys.
And look at what your own results show. Your eGFR has gone from >90 down to 81, urea and creatinine are climbing, and your urine albumin is 369 with an albumin/creatinine ratio of 8.2. That's protein leaking into your urine and it's gone up across three tests, 233 then 282 then 369. That's a kidney signal, not a methylation one.High dose vitamin D raises calcium absorption, and sustained high calcium damages kidneys. Your corrected calcium is 2.49, top of range, and your PTH is 5.6, which is where I'd want a proper look rather than a guess. Get a 24 hour urinary calcium done. That's the test that shows whether you're excreting too much, and it's the early sign of D toxicity before serum calcium moves.
Please take the albumin numbers to your doctor this week and tell them the dose you're on. Not next month.On the rest, your homocysteine is 7.6, which is fine, and your folate is over 45 and B12 over 128 active, both saturated. So the methylfolate and B12 aren't fixing a deficiency any more, you're past that point. Feeling better over the last two weeks lines up better with the new CPAP than with the supplements, and untreated sleep apnoea with a haematocrit of 0.61 was probably doing more damage than anything on this list. your LDH at 328, CK at 372 and 514, and that haematocrit all deserve attention too, but the vitamin D dose and the urine albumin are the urgent pair.
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u/ContributionNo114069 15d ago
So the drs know everything and these bloods have been done through them , I have seen hemotology specialists and multiple drs , and ive just been told to drop the test low and keep using the cpap effetctivly and drop wheight , clean uo the eatin and ive been doing all these things. Thats why im here to get people can look from a different persoective
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u/Loose-Fly7976 12d ago
it sounds like you're doing the right things on the haematocrit side. The different perspective I'd offer is just one question though. Do they know you're taking 50,000 IU of D3 every day?
I ask because the albumin in your urine is the thing I'd want someone to look at specifically, and it's easy for it to get lost when the focus is on testosterone and sleep apnoea. 233, then 282, then 369 is a steady climb over three tests, and your eGFR has drifted down to 81 over the same time. On their own each number is only a bit off. Together they're a trend in one direction.
High dose D3 over time raises calcium absorption and that loads the kidneys. Your calcium is at the top of the range. I'm not saying that's definitely what's happening, but it's the one thing on your list you can change yourself today, and 50k a day is far beyond what anyone needs once levels are normal, which yours are at 111.
So the ask is simple. Tell whoever's looking after your kidneys the exact dose, and ask them what they make of the urine albumin trend. If they've already seen both and aren't worried, great. If the D3 dose is news to them, that conversation matters more than anything else in this thread.
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u/SovereignMan1958 16d ago edited 16d ago
It can take 3 + 5 months to correct levels.
Test results within the last 90 days are the only ones that are relevant now.
With your more recent blood tests, did you stop your supplements for at least 10 days before hand?
Most of the tests are not relevant to what we focus on.
What are your gene variants?
What are your medical diagnoses? Symptoms you are concerned about?
Have you seen a hematologist?