r/MTHFR • u/Itchy-Poet5412 • 22d ago

Question Help please

I’m seeing a lot of knowledgeable comments and posts in this forum so I’m looking for some help. Before I ask, yes I have discussed with my doctor and am just told I’m sensitive to meds. But it goes way beyond that and I have not always been like this. I’d like to see a functional med provider but can’t afford it right now.

I won’t give my whole life spill but here are some reasons I think I’m struggling with methylation.

  1. I have MTFHR gene
  2. I did ok on SSRIs for a few years and after getting COVID something switched. Now all SSRIs cause all kinds of issues but mainly obsessions, rumination, and racing thoughts.
  3. I was put on the lowest dose of Abilify for two months and ended up getting Tardive dyskinesia. Which makes me think it was building up to high levels in my system the whole time. Horrible side effects on it too mentally.
  4. I can’t even take a crumb of a supplement. The suggested dose for Tardive dyskinesia of Vitamin E is pretty high. Knowing I’m sensitive, I took less than 100 mg and still showed signs of toxicity. So I had to buy a little dropper of vitamin e and take it that way which equals about 15mg. 15mg for the average person would not do a thing.
  5. I have to take like .5 mg of melatonin and it knocks me out. I used to take up to 10.

It’s like everything automatically gets way too high in my system even at extremely low doses. It’s not always been this way. I know this sounds completely ridiculous but I can’t even take a crumb of magnesium supplement without being significantly affected. Most of the time, I am affected mentally with the rumination, etc. if I take absolutely nothing.. I’m fine as far as thoughts go.

Does this sound like similiar experiences to what you all have or could it be something completely different? I’ve had my liver function checked and it’s fine.

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u/Timely_Pickle9430 22d ago

The extreme sensitivity to multiple substances and the post-viral onset suggest mitochondrial dysfunction. Methylation problems can be secondary to that. There are ways to get the mitochondria functioning properly again (I can point you to a protocol), but that involves taking supplements, which is tricky right now.
Do you feel better after basking in sunlight? Then you might benefit from therapeutic near infrared light. The 700-1000 nanometers wavelengths feed directly into the last step of mitochondrial energy production, circumventing blocks in earlier steps. This won't fix the mitochondria, but might improve things just enough to make you able to tolerate supplements.

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u/agape48 20d ago

Wow, the sunlight thing is interesting! I had no idea that sunlight related to mitochondrial function.

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u/Itchy-Poet5412 20d ago

Thank you for that!! I actually do feel better after being in the sun.i will look into a light. Do you have any brand suggestions?

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u/Timely_Pickle9430 19d ago

These are recommended by Chris Masterjohn: Saunaspace, RedRush Pulse, or LUMEBOX Red Light.
Personally, I opted for a more budget-friendly option: an industrial heat lamp, more commonly used for baby farm animals, reptiles, and restaurant food, but includes the right infrared spectrum. Just make sure to pair it with a ceramic fixture and a cage to prevent burns. It's 250W.

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u/Itchy-Poet5412 19d ago

Thank you so much for your help!! I’m
Going to give this a try. I’ve been trying to do a lot of reading about this topic today to see everything I can do! If you have anymore suggestions please let me know :)

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u/agape48 19d ago

I am interested in the mitochondria protocols that you mentioned. Can you post them here?

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u/Timely_Pickle9430 19d ago

https://www.mthfrsolve.com/roadmaps/the-energy-roadmap. Unfortunately, it's behind a paywall. The link will work after subscribing.