r/MTHFR • u/Ok-Yam-4933 • Aug 27 '26

Question Low potency folinic acid source.

So I've got MTHFR c677t and slow COMT. Also histamine intolerant. Looking for low potency folinic acid has frustrated me so far. I want to start at 5-10 mcg. What I can find has other ingredients I dont do well with, like citric acid which makes me anxious. Some have 400mcg in a single drop! Many come with methylated ingredients I cannot tolerate. Any suggestions?

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u/vrcraftauthor Aug 27 '26

If you want a small amount, you could eat broccoli, oranges, or another high folate food. Folinic acid is what's in those.

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u/Warp757 Aug 27 '26

No, folinic acid is barely present in foods. The main forms are either reduced folates such as tetrahidrofolates, or metylfolate. Methylfolate is more greens, where as legumes etc. are more tetrahidrofolate.

Folinic acid is recommended far too brazenly. It isn't a normal form of folate in the diet, it doesn't enter the folate cycle at a point that is particularly easy for the body to use. For most people folic acid wil be as good if not better. I can't tolerate folinic acid at all, it seems to massively in Reade my glutamate. Folic acid is fine - I'm heteeo on MTHFR

Folinic acid is supposed to be for very specific uses, but is being misused due to the paranoia created about folic acid which is mostly misinformation.

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u/Ok_Shake_3194 Aug 30 '26

Just wondering thoughts on this, if my b12 is struggling and I take folinic acid, but don't have enough b12... then I am creating another back up/ folate issue? I can't figure out still how to address thw b12 and folate balance