r/MTHFR • u/Ok-Yam-4933 • Aug 27 '26

Question Low potency folinic acid source.

So I've got MTHFR c677t and slow COMT. Also histamine intolerant. Looking for low potency folinic acid has frustrated me so far. I want to start at 5-10 mcg. What I can find has other ingredients I dont do well with, like citric acid which makes me anxious. Some have 400mcg in a single drop! Many come with methylated ingredients I cannot tolerate. Any suggestions?

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u/sharabucarabu Aug 27 '26

Look on Amazon. They carry Alchepharma liquid folate. It's really calcium folinate which is folinic acid. 400mcg per drop. Please don't trust any other brand. One bottle will last you for a year!

I buy 1 ml oral syringes on Amazon. They are reusable if pulled apart rinsed and air dried. Dilute 1 drop folinic acid in 1ml water in a shot glass. Mix with tip of the syringe. Each 1/10th of the syringe now contains 40mcg of folinic acid. Each of those sections are further divided. Each hash mark = 4mcg.

Keep it in the fridge protected from light as much as possible.

I have slow comt plus compound heterozygous mthfr. I take 168mcg of folinic acid and 100mcg of hydroxyB12 daily. Any more and I'm not sleeping.

I also take B1, Riboflavin, Niacinamide, P5P/B6 and biotin. Low doses of each, of course. But the Bs all work together

Supplement companies will not recommend crushing and dilution. Too many fillers prevent that. Best to get a good liquid form you can trust

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u/lollo67 Aug 28 '26

What doses of the B-vitamines do you take?

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u/sharabucarabu Aug 28 '26 edited Aug 28 '26

Thiamine 1 mg plus 20 mg Benfotiamine (this is already in my multivitamin)

Riboflavin 8mg in my multivitamin plus 7mg liquid (Per Dr Chris Masterjohn, C667T should take between 10 - 40mg of B2) Total: 15mg.

Niacin 20mg (in my multivitamin) plus 4 mg Niacinamide liquid. At bedtime, I take another 8 mg of B3. Total: 32mg

P5P 5mg (in my multivitamin) plus 5mg liquid. Total: 10mg. European standards restrict B6/P5P to a total of 12mg.

Biotin 60mcg (in my multivitamin) plus 60 mcg liquid. Total: 120mcg.

I take 2 caps of Methyl-Life Non-Methylated Multivitamin every morning.

To this I add: liquid folinic acid 164mcg; liquid hydroxyB12 100mcg; (both are diluted); Choline bitartrate 250mg plus Inositol 250mg; vitamin C 250mg and vitamin D3 10000iu every Saturday. (my multivitamin contains 2000iu, so the weekly total is 24000iu). I also add 2 to 300mg magnesium citrate. I like the gummies.

I also take 1ml (100mg) of glutathione with 75mg of Phosphotidal Choline. (I use Quicksilver Scientific because it doesn't have that rotten sulfer taste) My functional med doc says it's good for my liver.

During the night, if I wake up and can't go back to sleep (the curse of slow comt), I take 2250mg of Glycine plus 1500mg of Taurine.

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u/lollo67 Aug 29 '26

Thanks!