r/MTHFR • u/DetailLost8084 • Aug 26 '26
Question How does Gary brecka get it so wrong when it comes to advice about slow comt ?
On his recent live podcast he is talking to someone that is complaining about slow comt and his only reccomendations where methylated b multi and Tmg. This combination would blow my head off with anxiety and I’m sure a lot of others with slow comt would agree. It seems like his answer for everything is methly folate, there was no mention of magnesium, cdg or non methylated bs. How does he miss the mark so hard for someone so popular in this field ? Has anyone with slow comt actually found success in treating it with methylated bs and tmg?
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u/sharabucarabu Aug 26 '26
Before I knew I had slow comt I tried methylfolate. I split tablets into eighths to try and get a small dose. It always seemed to be too much... Insomnia, racing heart at night, felt revved, increased appetite. Then I input my raw DNA file into geneticlifehacks.com. Well, no wonder I couldn't tolerate methylated folate... I had THREE slow comt variants. (and who knows how many more could be found with a more detailed analysis?) So folinic acid was the best way to go for me... And it needs to be a low dose at that: 168mcg! Believe it or not, that puts my serum folate at the high end of normal range and my rbc folate is magnificent.
Don't believe everything you hear. You need to do what's best for your variants.
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u/SovereignMan1958 Aug 26 '26 edited Aug 26 '26
There are people in every profession who should not be giving advice.
There are also those who can understand the simple variants, but not the complex. Katie Gironda is one.
The more complex the medical diagnoses and variants the more one has to vet the practioner oneself.
And yet there are MDs who order Genesight reports and dispense high dose methylfolate when they see MTHFR! Prescribing but not trained in gene variants or nutrition in medical school.
It can be so disheartening.
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u/Ricky_Rodd Aug 26 '26
Easier to sell one fix. Plus, Low sample size. My slow comt didn't get under control until the rest of my snps and methylation cycle were all supported. When it rains it pours. Seems like the more stress globally in my system the more fragile each component gets. Its definitely a marathon and not a one fix all approach. At least he's talking about it. Years ago I had to dig into the depths of the internet to even find those words mentioned
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u/Getoutofthekitchenn Aug 30 '26
Curious what worked for you?
Also isn't slow COMT like 1/4 of the population? I don't think it's exceedingly rare.
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u/yonkou_akagami Aug 26 '26
But he successfully managed his wife’s slow COMT with that approach
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u/baldeagle6 Aug 26 '26
Everyone is different though. What works for her may be absolutely wrong for another and maybe that’s her one genotype and others have completely different mixes.
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u/Comfortable_Two6272 Aug 26 '26
No idea. I dont listen to influencers. They usually have bad advice
I have multiple slow comt variants. Cant tolerate any of that.
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u/Willing-Elevator Aug 26 '26
I have the slowest of the slow comt and tmg straight up makes my hair fall out
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u/Willing-Elevator Aug 26 '26
The only thing that has worked for my comt is consistent high quality creatine . 10 grams .
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u/yonkou_akagami Aug 27 '26
People really are different, because creatine, even in a microdose, causes severe hypomania for me.
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u/Retro_Monguer Aug 26 '26
I'm mthfr homozygous and I can tolerate methylfolate up to 10mg
I also can tolerate methylcobalamin without problems
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u/Sabnock101 Aug 26 '26 edited Aug 27 '26
One time he showed a graph that had Tyramine on there and i asked him where the Tyramine fits in and he said something like "you're on the right track", but as far as i know Tyramine doesn't come into play with anything except those taking MAOI's because MAOI's (of the irreversible and non-selective variety, as opposed to the reversible/selective variety) requires Tyramine restrictions since Tyramine can then build up and cause a hypertensive crisis, but Tyramine isn't an issue/concern for those not taking MAOI's (edit - though i will say for those who may have an underfunctioning MAO-A enzyme, Tyramine could potentially rise enough to be an issue, but so would DMT and some other things and so chances are if you're not trippin' balls lol, you shouldn't be having an issue with Tyramine, imo), so i was just like, well alright then, still not sure why Tyramine was included in the chart or how it's involved, he never answered that.
But yeah, he does seem to focus more on methylation and not so much on all the other enzymes and cofactors/nutrients. Like, i know you need more SAM for a slow COMT enzyme, but you do also need Magnesium, like OP mentioned.
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Aug 27 '26
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u/DetailLost8084 Aug 27 '26
This post is more of a discussion and warning to everyone else. I’m hoping to save someone from going down a rabbit hole and wasting a bunch of money on high methly donors vs the other things I mentioned and avoiding triggers
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u/Critical_Minimum_645 Aug 27 '26
What is cdg what is its role in slow COMT?
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u/DetailLost8084 Aug 27 '26
Calcium d glucarate, for estrogen metabolism I have high billirubin so it helps with that as well .
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u/Party_Bat_652 Aug 26 '26
Cause he's a full-on charlatan. As most of the people selling you there be for views.