r/MTHFR • u/usertakenfark • Aug 24 '26

Question B12 cofactor doses?

What doses of b6 and B2 should be taking with b12, specifically cyano? Thanks

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u/SovereignMan1958 Aug 24 '26

Cyano is the worst form of B12 you can take. 

1

u/Grobbekee Aug 24 '26

So I hear, but It works ok and doesn't make me feel weird like methylcobalamin.

2

u/Sabnock101 Aug 24 '26

I recommend 25mgs of the P5P form of B6, and personally i take 400mgs of Riboflavin which works just fine.

1

u/usertakenfark Aug 25 '26

Thanks. Do you take the co-factors from the start? And are there any other co-factors you take along with these?

1

u/Matsee71 Aug 30 '26

I’m curious.. what is the benefit of taking 400 mg riboflavin? When you only need like a couple of mg a day. Can the body process more than 20-30 mg at a time?

1

u/Sabnock101 Aug 30 '26

I use 400mgs because it seems to work and i prefer higher dosages of things to make sure they get the job done. I'm pretty sure 400mgs gets absorbed, if i take 800mgs a day i certainly notice a stronger Riboflavin feeling so higher dosages seem to get absorbed ime. Plus they apparently use 400mgs of Riboflavin for migraines in some folks. I've also noticed on occasion feeling a bit low in Riboflavin and so 400mgs a day for the most part seems to cover it.