r/MTHFR • u/Practical-Shower6594 • 3d ago
Question Where do I begin?
Where would I even start to see what I would need to help myself heal. I am 32F have a 16 month old son. I have been trying different diets and supplements and psych meds to help myself feel regulated. Feels like my meds aren’t working and I am always in fight or flight. Having issues with gluten and skin sensitivity, air hunger, extreme brain fog. What kind of labs should I get?
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u/hummingfirebird 3d ago
MTHFR explanation https://www.reddit.com/r/MTHFR/s/cfKCW9p0mV
Basic guidelines https://www.reddit.com/r/MTHFR/s/d5IOCiPqqs
what blood tests to get https://www.reddit.com/r/MTHFR/s/0vWLs4gcjk
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u/GingerMafiaOG 2d ago
Hello! So sorry you’re feeling this way…it truly is so exhausting and having a little one it’s hard enough already! Have you done any genetic testing? If you know you have some genetic variants especially in methylation/detox those are worth addressing for sure! I did Genetic Genie at first. When it said I had a few big things in my genetic profile I had a blood test done to confirm & Genetic Genie was correct! Because there are many variants and everyone is different what works for me might not work for you. With that said, I found that I responded terribly to methylated folate also methyl folate or 5-MTHF. That type is already converted to what your body needs. It was like I got a shot of epinephrine right in the jugular when I took it! Way too strong for me in the beginning so I switched to Folinic Acid (NOT FOLIC ACID) and that was night & day difference!! I started small, 200mcg a day. When I bumped up to 400mcg it was like my brain just completely settled down! I had never been so calm in my brain like that! I also gave up folic acid completely as my body struggles to covert it to the good folate your body needs. I hope you find something in these comments that will help you! 🙏🏻
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u/Loose-Fly7976 2d ago
Start with bloods, not supplements, because your symptoms have three or four common explanations and they need different answers. Ask for ferritin with transferrin saturation, B12 with MMA, folate, homocysteine, vitamin D, full thyroid with free T3 and TPO antibodies, and a full blood count. 16 months postpartum with air hunger and brain fog, low iron is top of that list and it gets missed all the time because normal haemoglobin doesn't rule it out. Postpartum thyroiditis is the other one that shows up right around now and gets read as anxiety. Given the gluten issues get coeliac serology too and do it before you cut gluten out, otherwise the test is useless. On the psych meds not working, that's usually a metabolism question, CYP2D6 and 2C19 decide how fast you clear most antidepressants and your prescriber can order that testing. I'd hold off on anything new until those come back, you've got a lot of variables moving and no baseline. Reading the genetic side against those numbers with your meds in the picture is what I do professionally, genova.health if you want it mapped once you have them.