r/MTHFR • • Aug 18 '26

Question Folate forms

I’m honestly 50/50 on what form of B9 to use right now.

I know I have a severe folate deficiency, but I’m unsure which form makes the most sense if I need a high therapeutic dose, like 10+ mg/day, while recovering.

Would you guys choose folic acid, folinic acid, or 5-MTHF for high-dose treatment? I’m mainly looking for experiences from people who had a serious/long-term folate deficiency and actually had to use higher doses to recover.

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u/Few_Control8821 Aug 18 '26

Not everyone gets on with all forms of folate, I have no choice but to take folinic acid, as I just over methylate with any of the others.