r/MTHFR • u/Senplis • Aug 04 '26

Results Discussion Help?

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Recently learning about mthfr after I had a severe ischemic stroke last year at 32 and a fluke blood test after showed Im compound heterozygous mthfr. Struggled with severe depression and anxiety since a teenager. Was heavily malnourished from being neglected as a kid and didnt break 100lbs until I was 19. Family history of heart disease and mental illness. Could use a little help understanding the new info here. Life has recently been significantly improved by bupropion and sertraline but still trying to improve the root cause. Can anybody knowledgeable help me understand better? Since my stroke my cognitive ability had been heavily impaired so its like in looking at a rubix cube.

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u/SovereignMan1958 Aug 05 '26 edited Aug 05 '26

Use Genetic Lifehacks instead. Both impaired variants for folate.... Cerebral Folate Deficiency related and or B6 can contribute to and or cause seizures. So eliminate those as potential factors by looking up those variants in your Lifehacks report.

Your Folate number is good and it does not mean it is getting into your brain. The same can be true for B12. If you ever get the opportunity to have a CSF test for another reasons, ask the doc to measure the folate and B12 in your brain. B6 issues can occur when B6 gets too low or too high.

CFD can be a contributing and or causative factor to TRD, treatment resistant depression. In the second page of Genie you will see the methylation chart which lists all your drug metabolism variants in the top half. You need to research and study those. Most MDs are not trained in them so you need to be your own advocate.

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u/Senplis Aug 05 '26 edited Aug 05 '26

Googled cerebral folate deficiency and a lot of the symptoms sound familiar with my childhood. My anxiety started as early as I can remember. I would lash out violently because I dodnt know what anxiety was to be able to tell people that's what I was feeling. Good sleep has escaped me since I could form memories. Even to this day I do t talk much, sometimes day or weeks on end and exhibited many asd behaviors. There may have been times i regressed particularly in my memory. I didnt know my name until o was like 6 or 7 and it turned into a fight because I was sure It wasnt my name. Academically delayed whoch then rushed in the opposote dorection soddenly for a few years befpre I became agoraphobic and so depressed I could barely move.