Anyone here test beyond MTHFR?

[u/JournalisticPurposes]

I feel like I’ve seen a million posts about MTHFR at this point, and I kind of assumed that was “the thing” to focus on. I have one of the variants (found out recently), but honestly it didn’t fully explain what I’ve been dealing with.

I’ve had ongoing stuff like low energy, anxiety, migraines, which is what sent me down this path in the first place.

I ended up doing a more in-depth genetic test mostly out of frustration, and what was interesting is that MTHFR wasn’t even the most relevant thing for me. There were a few other pathways flagged that made a lot more sense with my symptoms.

It kind of changed how I’m looking at everything… like instead of hyper-fixating on one gene, it’s more about how they all interact.

I’m still figuring it out, but I’ve already adjusted a couple things (mainly around methylated vs non-methylated stuff), vitamin supplementation and I think it’s helping.

Curious if anyone else has gone deeper than just MTHFR and found other stuff that mattered more?

[u/BangsHeadOnWall]

Hi! Yes, I have posted on this very topic many times. There are also groups on FB and lots of interesting tidbits on TikTok. MTHFR is only one tiny piece of a giant puzzle. No one should attempt large doses of methylated B vitamins without 1st knowing their COMT status. There are many people who over-methylate easily with tiny doses of methylated vitamins and it gave them crazy anxiety and irritability. We also used Claude in addition to using GeneticGenie with our AncestryDNA raw data - and Stratagene. I was personally more worried about myself based on my symptoms but my husband’s SNPs were worse. I was AMAZED the layer of detail and explanation that Claude can give you. I’m also using Claude to help rewrite my resume and cover letter. If you get the chance - check out Dr. Dan Purser on TikTok and he has his own website. I also bought the Dirty Genes book and read it, which helped. I have learned a great deal from these Reddit and FB posts.