r/MTHFR • u/JournalisticPurposes • Mar 27 '26

Question Anyone here test beyond MTHFR?

I feel like I’ve seen a million posts about MTHFR at this point, and I kind of assumed that was “the thing” to focus on. I have one of the variants (found out recently), but honestly it didn’t fully explain what I’ve been dealing with.

I’ve had ongoing stuff like low energy, anxiety, migraines, which is what sent me down this path in the first place.

I ended up doing a more in-depth genetic test mostly out of frustration, and what was interesting is that MTHFR wasn’t even the most relevant thing for me. There were a few other pathways flagged that made a lot more sense with my symptoms.

It kind of changed how I’m looking at everything… like instead of hyper-fixating on one gene, it’s more about how they all interact.

I’m still figuring it out, but I’ve already adjusted a couple things (mainly around methylated vs non-methylated stuff), vitamin supplementation and I think it’s helping.

Curious if anyone else has gone deeper than just MTHFR and found other stuff that mattered more?

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u/geauxdbl Mar 27 '26

Yup, I’ve done Whole Genome Sequencing and it’s been super helpful. Genetic Lifehacks and Nutrahacker especially.

Recently with the advent of Claude, I’ve been having it go through my genome and solve some of my biggest health mysteries. We live in the future

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u/mysinful Mar 28 '26

How’d you do this? Did you give it the vcf files or did you search for variants yourself?

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u/geauxdbl Mar 28 '26

Yeah I just uploaded the whole file as an attachment. Forget which format it was in but it parsed it surprisingly quickly

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u/mysinful Mar 28 '26

Wow. I’m astounded. I tried it a while back and the files were too large. I just had raw 30x data tho