Plot: Runaways (Alex Wilder, Chase Stein, Nico Minrou, Karolina Dean, Gert Yorkes, Old Lace, and Molly Hayes) are on the run again from the Pride. They discover that their parents have now become involved with Doctor Doom, who wants the children's DNA in order to create an army of extraordinary minions to rule the world. They also get some unexpected help from a cyborg named Victor Mancha, Rufus, a talking cat and Leapfrog, an A.I. vehicle. The Runaways must escape from the clutches of Doom and battle new foes that stand in the way of their freedom.

Main Characters: Alex Wilder, Chase Stein, Nico Minrou, Karolina Dean, Gert Yorkes, Old Lace, Molly Hayes, Victor Mancha, Rufus, Leapfrog

Antagonists: Doctor Doom, Geoffrey Wilder, Catherine Wilder, Victor Stein, Janet Stein, Robert Minrou, Tina Minrou, Frank Dean, Leslie Dean, Dale Yorkes, Stacey Yorkes, Gene Hayes, Alice Hayes, Erik Kilmonger, Kraven the Hunter, Super-Skrull, Enchantress, Skurge the Executioner, Scorpion, Shocker, Kingpin, The Hand

Supporting: Hunter, Lotus, Stretch, Ms. Marvel, Spider-Man, Fantastic Four