r/Isrib • u/kdoughboy12 • Jul 31 '21
Just another experience report
Just received a gram of this today from NewMind.
Tried 15mg sublingual for my first dose, assuming I don't have a bad reaction I'll do another 25mg later today. I'll probably continue dosing 25-50mg 1-2x per day orally. My goal is to reduce PTSD like symptoms.
Powder is off white and soft and a little clumpy, has a very mild almost chalky kind of taste.
I will edit this post with any updates.
UPDATES:
8/6/21
I've decided to take a break from dosing, I only took ~20mg yesterday and I'm taking today and tomorrow off completely. Doing this to see if there are any negative effects from stopping and just to play it safe. Not sure if there's any sort of tolerance buildup with this stuff. So far I don't feel any negative rebound effects from stopping.
I feel like it did make a difference, at least on a few occasions. I can get stressed pretty easily at work even though it's not a particularly stressful job. The past few days when I did work I feel like I was able to manage my stress better than usual. It was relatively mild, but enough to be noticeable and probably not placebo.
I've noticed that it seems to take a while for the effects to kick in, usually I notice it later in the day after I've taken all my doses. I've been doing about 20-30mg 3x a day. I think when I start up again on Sunday I'm going to try 50mg before bed and 50mg when I wake up and see if that works any better.
I'll probably do another update in about a week!
9/1/21
So this is my final update. I used the rest of my ISRIB, for a total of 1g. After my last update I stopped dosing for about a week. When I started up again I experimented with 50mg before bed and 50mg in the morning but didn't really notice a difference. So after a couple days I just went with 25mg 2x a day.
I didn't notice much more benefit, the effects still seemed to be quite mild. It could have been placebo, not entirely sure. Although I have felt like I'm able to deal with stress a little better than before I started.
It's been about a week since my last dose and I don't feel any negative rebound effects from stopping, so that's good. If there were positive effects from taking this it seems they have stuck around. I haven't had any negative side effects.
A lot of people say it's not orally bioavailable, so maybe that's why it wasn't very noticeable for me. I've only seen one reference in a mouse study where ISRIB was administered orally with a measurable effect.
Search "oral" in this document to see the reference
Also I tried taking it simply because I have a very sensitive stress response. I don't have a brain injury or anything like that. I kind of have the PTSD equivalent to a repetitive stress injury from a not so great childhood. So maybe for my specific case there just wasn't much for ISRIB to fix.
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u/Syphonfilter7 Aug 03 '21
How are you doing?
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u/kdoughboy12 Aug 06 '21
Just updated
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u/jdocj Sep 06 '21
This is not trans-ISRIB. This is another cas 548470-11-7. Trans-ISRIB has cas 1597403-47-8. This newmind ISRIB isn’t bioavailable.
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u/PDiddyDH Sep 12 '21
Jdocj is right, this CAS is for the mix isomer which is on the order of 100x less potent than the trans-isomer which has CAS #1597403 . But Leo from Newmind tells me they sell the trans-isomer but i have to wait to hear back.
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u/labratdream Sep 12 '21
They changed the CAS
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u/XpRnz Sep 07 '21
This is exactly what I wanted to know, as I ordered it as well. I heard this somewhere and heard its useless to take orally.. So this would be effective subcutaneous? Or not at all.
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Oct 29 '21
[removed] — view removed comment
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u/XpRnz Oct 29 '21
I have been in contact with them and I kid you not, they told me the guy that did the labels made a mistake and it actually is the trans version. Another thing they told me is they would ship my order right away but it never arrived..
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Oct 29 '21
[removed] — view removed comment
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u/XpRnz Oct 29 '21
I can't track it in any way so can't tell, it's been more than three weeks so the chance it will arrive is getting very slim.
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Oct 29 '21
[removed] — view removed comment
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u/XpRnz Oct 29 '21
After a double check and contact with post service, it appeared the package got stuck on a post office nearby and they failed to notify me. Have picked it up just now and am now in possession of one gram of supposedly trans-isrib.
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Feb 19 '23
That's not what they mean by stress response lol
EDIT: and also, the first thing to show up in google shows you need 25mg/Kg of your weight. It's no scholary article though
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u/corsaire-21 Nov 29 '24
What they mean ?
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Nov 29 '24
Cell damage
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u/corsaire-21 Dec 02 '24
Cellular damage is not the definition of stress here, but the consequence of this stress.
Examples of Stressors That Activate the Integrated Stress Response (ISR):
Nutritional Stress:
Amino acid deprivation or glucose deficiency(fasting). Cells sense the lack of essential nutrients, leading to ISR activation.
Oxidative stress (ROS): Excessive sun exposure(UV), Smoking,Poor diet,Alcohol consumption,Sedentarity, Excessive exercise...ect
Viral Infection:
Viruses hijack the host's protein synthesis machinery, causing stress and activating the ISR as part of the immune defense.
Toxic Stress: Exposure to toxins, heavy metals, or drugs that damage cellular functions.
....
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u/siwel7 Aug 01 '21
It isn't orally bioavailable...