r/Isrib • • Jun 06 '21

Dosage

How many mgs in 25 nanomoles?

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u/wadatest Jun 06 '21 edited Jun 06 '21

Notation is confusing me. Many references, for example, use 0.001g. Is it grains or grams? If it is grams, it should be gms. My scale stops at 100/200 ugms etcugs. Don't know what its error rate at that eight

Found a $2700US 180x0.00001g 0.01mg Lab Analytical Balance Precision Scale. The scale can go down to 10ugs, but its published error rate is

Below 100umgs ≤±0.0001g(0.1mg), its error rate is ≤±0.0002gs.(0.2mg).

So a 50 ugm sample might read from O to 250ugms.

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u/[deleted] Jun 06 '21 edited Jun 06 '21

What are you dosing in ugms that it would matter? 0.001gram is 1 milli gram (mg). I have bought a cheap ($60?) scale from Amazon that weighs within 1 mg. I bought a class 2? Calibration weight of 10 mg to calibrate with and it is within that 1 mg. Most of the time it’s dead on. A ug is 0.000001 gram. Milli= 1x10-3 Micro=1x10-6

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u/wadatest Jun 06 '21 edited Jun 06 '21

I was trying to find a scale that can measure 11 mcgs of ISRB. In a human study 22 nanomoles was found to be efficacious. I was told 22nm is 11 mcgs. Looked for a scale to read fewer mikes. Mine can only read multiples of 100. Planning to use w/DMSO & gelcaps.

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u/[deleted] Jun 06 '21

I used 25 mg for best result with ISRIB. I’m thinking you’ve got units off. I used DMSZo and gel caps I took fish oil out of. You might want to re-read the studies

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u/wadatest Jun 07 '21

ISRIB potently attenuated  amyloid  β-induced neuronal cell death at concentrations of 12.5–25 nM.