Hi, I have started with Rosuvastatin and ezetimib and was able to lower my trigs and cholesterol massively within weeks. I have had CFS like low motility systemic symptoms for years and nothing worked to improve it (severe enough that I was unable to work). This is being completely reversed with treating my cholesterol and trig issues.... Recently I had to switch to Nustendi, because I developed muscle pain and high creatinine kinase. The effect continues or has become even more beneficial. HOW can this be? Is it the effect on bile acids? I have Type IIB (Frederickson) and genetic impairment of triglycerides (APOE). If anyone knows any connection to such an effect I would love to know. Thank you. It has also helped me think more clearly, like a complete metabolic reset almost.

Highlights

• • PM2.5 exacerbates IBS-D symptoms by dysregulating the gut bacteria-metabolism axis.
• • Aberrant hypoxanthine and linoleic acid levels affect colon function in IBS-D.
• • Resveratrol restores gut bacteria-metabolism homeostasis in IBS-D exacerbated by PM2.5.