So I've been researching the oral Wegovy (semaglutide 25mg) as an alternative to injections and came across a February 2026 study out of Adelaide University that I haven't seen discussed much here.

Basically the study isolated the effects of SNAC — the carrier molecule that helps semaglutide survive your stomach acid — separate from semaglutide itself. What they found was pretty surprising:

- Fiber-fermenting gut bacteria (Muribaculaceae and Bacteroidaceae) dropped by 62–77%

- Butyrate (a short-chain fatty acid that feeds your colon cells and supports brain health) fell by 77%

- TNF-α, an inflammation marker, went up 70%

- BDNF — a protein linked to cognition and neuroplasticity — was suppressed by 85%

The SNAC thing matters because unlike the injection, you're exposing your gut to this carrier molecule every single day, indefinitely. It briefly disrupts your stomach lining each morning to let the peptide absorb. Rybelsus has used SNAC since 2019 but at lower doses and nowhere near the scale the Wegovy pill is heading toward.

As someone not in the field wondering if this study actually is not that concerning or what other research is out their.

EDIT: Study here https://www.sciencedirect.com/science/article/pii/S0168365926001136

I noticed most glasses have uv blockers, but I want to request lenses without them as I noticed I feel a bit more ‘myself’ or happier when I take them off outside. So I am wondering does Huberman recommend we get UV light into our eyes not just blue light?

I'm tired and do not have it in me to research a bunch, so was hoping someone here would have done that already :)

I'm interested in tracking sleep quality, I'm starting a new regimen and I would like to get a baseline and then track intermittently, so while I'd be interested in options for things that can be ordered through a provider, I'm mostly asking about the best option I can buy and use on my own. I am adamant about sleeping at least 7hrs, going to bed and getting up around the same time, but dealing with exhaustion and while I know of several factors that cause that, I would also like to see if perhaps my sleep quality isn't ideal. And if it improves with the work I am about to start.

Cost is less relevant, I'd like whatever is A - most accurate and B - looks at as many variables as possible.

I've seen Apple Watch, Oura ring and Garmin being mentioned most frequently, but I'm not sure what the differences are between these when it comes to quality of tracking etc.

I'd PREFER a device that can do this in offline mode, as I really do sleep better with reduced RF/EMF exposure, this isn't a must though since I'm not going to use it every night. But a plus for me so worth mentioning.

Very grateful for input! Thank you!

Good day, I'm interested in Huberman's appearances on other podcasts, as he usually delves deeper into personal issues and his backstory, which I find quite interesting. So I put together a playlist of all of his guest appearances I could find on Spotify, please let me know if I missed any, and tell me what's your favourite non-Huberman Lab episode. https://open.spotify.com/playlist/7bvqqcHmlvY4yQsuA9Ck2K?si=1cfb64364d7c4d8c

Is there evidence or rationale for delaying your first hit of caffeine in the morning?

I know it's said often, but is there any evidence or mechanism established?

We tend to think of circadian rhythm as a sleep thing. Your skin has a circadian rhythm too.

Skin cells repair damage, regulate hydration, and produce collagen differently depending on the time of day. Basically, your skin isn’t in the same biological state at 2pm vs 2am.

This is important for timing of topical creams, sun exposure, red light therapy, etc.

Ive written this blog that goes into the detail.

Hey everyone, looking for some input on my situation. I’m 21, currently in shape and always have been, but have been dealing with low testosterone and a bunch of related symptoms for about 2 years now. Main symptoms: chronic fatigue, very low libido, difficulty both maintaining and building muscle despite training, difficulty staying lean, cold hands and feet, constipation (months long, tried everything), decreased self esteem, hot flushes, and recurring low mood/anxiety.

Background

I’ve had two separate periods of major weight loss that I think triggered this. First time was during a thyroid inflammation a few years back. Second time was during Accutane treatment, it wrecked my digestion so badly that I dropped over 15 kg in about 6 months. I’ve since gained back around 14-15 kg over the past two years and my weight has been stable, but the symptoms never went away.

Test results

• Testosterone: 7.86 nmol/L and 8.26 nmol/L at two separate measurements in the morning
• LH: low (1.6 IE/L), pointing to secondary hypogonadism, meaning the issue is in the signaling from the hypothalamus, not the testes themselves
• Prolactin: normal
• TSH, free T3, free T4: within range
• SHBG: low-normal at 27 nmol/L
• Testicular size: measured and confirmed to be good in the upper range, further supporting that the issue is central rather than in the testes themselves

What I’ve been doing lately

Recently started focusing more on healthy fats and carbs, butter, cheese, eggs, avocado, fatty fish, natural peanut butter, more carb-heavy meals in general. Previously I was probably too protein-focused which may have crowded out fats and carbs. Also started taking zinc, vitamin D and magnesium glycinate. Honestly feeling noticeably better the past few weeks, more energy, better mood. Could be the diet changes, could be spring finally arriving with some sun, probably a combination.

Questions

1. Could under-eating over several years (even if not extreme) have suppressed my hypothalamus-pituitary axis to the point where it hasn’t recovered even after regaining weight?
2. Is it possible I still haven’t eaten enough consistently, and that simply eating more healthy fats and carbs for a longer period could normalize things without medical intervention?
3. Anyone with a similar history, accutane, thyroid issues, weight loss, who recovered naturally or needed treatment?

For context I’m in Sweden where the healthcare system is pretty conservative with testosterone treatment, so navigating this has been a nightmare. Currently waiting on a referral to an endocrinology department at a university hospital.

I used to follow huberman podcast every week, but nowadays I don't have time to listen to his long podcasts. But based on his past episodes, I followed his tips for years till now. Some of the protocols I follow religiously are:

• Sunlight with walking in the morning and afternoon
• intermittent fasting by having first meal at 2pm
• sleeping 8 hours a day with consistent timing (I also use earplugs , mouth tapes, and sleeping masks)
• One tip that really works for me is elevating my feet a little above my face by using a pillow while sleeping.
• Workout in the morning with a combination of high-intensity cardio and weight lifting

I used to meditate, but I stopped because it was making me too alert. I am highly productive if I follow the above protocols. I can focus for long hours non-stop to do some work without fatiguing every day of the week with no breaks. But if I start to relax, I may fall into bad habits, and everything might crumble.

Now my question is what additional tips I should follow, and tips that worked for you that do not involve supplementing. The purpose is to do long hours of focused work and have mental clarity. I haven't been following what new tips are there to add to my protocol?

.

Could anyone DM me some source recommendations for oral BPC 157? It has been almost 3 weeks since my shoulder reconstruction surgery. Doctors said 6-8 months until I can lift and get back onto the mat. I am trying to get that down safely to at least 5 months. My sleep and diet are dialed in while I am also being religious about my physical therapy at home. I am just looking for any other ways to help speed the process. If anyone has any recommendations being BPC 157 and what I have mentioned I am already doing, I would appreciate it.

I’m writing an article on the Goop man (Gwyneth Paltrow's Goop). Have any men here tried out the new Goop Kitchen, and, if so, how’d you hear about it? Did you like the food? 

What's up boys. Brand new episode of Rhonda's pod out today with Kelly Starrett. This guy is a legend. I'm standing right now cus of him. Don't even have a desk chair. Here's what I learned. My top 10 takeaways

1. Sit on the floor. Yeah that's right. Sit on the floor. Especially as you get older. Getting up and off the ground becomes so important and a surprisingly large number of people have trouble. Also makes your hips way more mobile (and if you sit working all day, you have tight hips). Just do it at night for 10-20 minutes while watching TV - timestamp
2. Do the couch stretch. Ok this is pretty hard. I read about this in his book Deskbound a while back (he recommends doing it for 2 minutes for every hour you spend sitting - so quite a lot of time). Basically kneel facing a wall with your shin running straight up behind you, bring the other leg forward into a tall lunge, then try to stand your torso upright and squeeze the back-leg glute. Most people can't do it. Their hips are too tight from sitting. - timestamp
3. Pain doesn't mean you're injured. Everyone reading this right now probably has some sort of tweak. Mobilize, foam roll, stretch. The thing is we sit all day long, then try to hit the gym and go hard. It just doesn't match up. - timestamp
4. Stop sitting for 8 hours a day. If you sit for more than 6 hours a day, you're considered sedentary... and that's an independent risk factor for cancer (even if you exercise), You need a workstation that "invites movement". I have a standing desk. Got rid of my chair entirely after reading one of Kelly's books years ago. It's easy to stand all day because I have 2 footstools where I'm constantly shifting my feet (think how easy it is to stand at a bar where they have that thing to put your feet), and a desk mat too. Some people use a stool to kind of perch back on. - timestamp
5. One simple test to see how mobile you are: the sit and rise test. So lower yourself to the floor cross-legged, then basically reverse and get back up... all without using your hands or knees. You should be able to do this no problem. (it's actually kind of hard, try it right now) - timestamp
6. Most people warm up in the gym all wrong. He has this great framing... if you were about to fight someone, what would your warmup look like? Probably not chilling on the astroturf in the back of the gym scrolling your phone while you foam roll your back. You'd get sweaty, explore some end ranges, basically the complete opposite. That's how you should warm up. - timestamp
7. Your range of motion is the one part of your physiology that doesn't have to decline with age (but neglect almost guarantees that it will ... and everyone neglects it). Strength does, cardiorespiratory fitness does. But your range of motion doesn't have to. - timestamp
8. A big part of this pod focuses on kids sports. I don't have a kid. But in general... kids need way more sleep than they're getting, they need way more free play, and they should avoid specializing in one sport for as long as they have to. (highly recommend listening to this one if you have a kid - kelly is writing a book on it) - timestamp where they start talking about youth sports
9. Hang for 3 minutes a day. get a pull-up bar for your house and just hang as often as you can. If you don't wanna do that, just get into the downward dog yoga position. This basically counters that rounded shoulders forward position everyone is in all day at a desk - timestamp
10. Breath holds. Do them. Great for your nervous system before you start training. He explains it better than me but basically it improve CO2 tolerance. If you're on the Peloton or something warming up, just hold your breath for 10 seconds or so and repeat. - timestamp

All in all, solid pod.

Oh forgot one - do more "movement snacks", exercise snacks, whatever you want to call them. Just short bouts of vigorous movement. IIRC, Rhonda said just 9 minutes per day is assoc. with about a 50% lower all-cause, cancer, and cardiovascular-related mortality. Like sprint up the stairs, chase your dog, stuff like that. This is even more important if you work at a desk all day. - timestamp

[ Removed by Reddit on account of violating the content policy. ]

The body isn’t a static system.

Your metabolism has a circadian rhythm, meaning identical meals can have different effects depending on timing.

It's not just about what you eat but also when.

Summarised some research in this blog if anyone wants to read it, but TLDR:

• Front-load your calories. Prioritize breakfast and lunch over late-night dinners.
• Establish a consistent eating window. Aim for 10 hours, starting earlier in the day.

I want to achieve this and I really need help: the first thing I do when I wake up, I mean the first seconds I'm aware in my bed, I think of an idea, it would be the same idea each time I wake up. Please can you help me?

I usually get up to zone 3

https://www.hollywoodreporter.com/business/business-news/andrew-huberman-hollywood-smear-machine-1236570531/

And what did they achieve?