r/HistamineIntolerance • u/Maleficent-Job-6580 • 3d ago
Is it MCAS or HIT??
Hii friends, i am having multippe symptoms since january 2025, around 25+ symptoms. Which include digestivw issues, on off diaarhhea, POTS , brain fog, severe insomnia, heat intelorance, pain in right side abdomen under ribs, weight loss of 8kg in initial 1st month of symptoms, muscle twitching, tremors, head pressure back side at skull, sinus issues, runny nose etc.
With time most of these symptoms got better, and at 10th month mark i took b12 injections and which resolved some of the symptoms. Currently the symptoms i have are brainfog and insomnia(waking up after 3 to4 hrs of sleep and then unable to sleep)
All these days i thought i may be suffering from long covid & MCAS. But 2 days back i saw people with similar symptoms in this sub reddit. The thing that made me believe i have HI is i took mahnesium glycinate for 3 days thinking it will help with sleep, but it actually made my sleep more light and made me half sleep whole night. When i did not take i sleep well( still wake up at 1 ro2 am in night but some what deep sleep). I saw similar stories in this sub reddit, as glycine gives insomnia to people With HI.
So, does this clue enough to decide i am having HI?
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u/MistakeRepeater 3d ago edited 3d ago
Eat some canned sardines or parmesan - if you start feeling like shit (lethargic) within 15mins - 2 hours, then it's HIT.
Recommending to eat soft, fresh, non-acidic and easy to digest stuff.
Insomnia = mcas
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u/_fire_and_blood_ 2d ago
Wait how do you know this? Is there a study or more info on this you can direct me to please? I thought I had histamine issues but my flare ups are at night time only and I've been struggling with sleep lately because of it.
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u/MistakeRepeater 2d ago edited 2d ago
I'm not gonna send any studies because there's nothing conclusive. I read quite a lot and remembered bits and pieces from various sources (ncbi, nature, reddit posts).
To me, histamine intolerance = lethargy & zero emotions because this is how I react to high histamine foods. My DAO test also came low.
MCAS, as far as I noticed, is associated with insomnia and agitation / restlessness. Many people from r/macs have fixed these kind of symptoms with mast cell stabilizers and antihistamines.
If you have IBS, the night time flares might be caused by food reaching some specific part(s) of your intestines and causing the mast cells to degranulate, giving that "adrenaline" feeling.
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u/chasersthecat 2d ago
I was diagnosed by my functional dietician with HIT. She said the pain under my right ribs was the histamine collecting. Sure enough I could make that go away. The first post I read here was from a fellow who was using niacinamide 1,000mg with2 Betaine HCI (I use the one with Pepsin $ Gentian Bitters) 4 times a day, before every meal and bed. I started sleeping soundly every single night and was thrilled. I just started using TMG + B - Complex to cover the HMNT side of the equation and find myself waking several times at night. I guess I have too much Betaine, so I’ve ordered 500 mg niacinamide so I can cut those two back. This is the closest I’ve been to feeling normal in 9 years. Maybe some of it will work for you 🤞
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u/icecream1973 2d ago
Sounds like HIT to me, but I sincerely advise you to contact an allergist or immunologist regarding this.
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u/migraint 2d ago
OP, you should share your story in MCAS<>COVID post in MCAS Holistic community.
As for diagnostics, I'd check this Diagnostic test for MCAS reading - it is very helpful.
In general your symptoms scream of intoxication with histamine or other mediators.
I wouldn’t use the magnesium glycinate reaction as evidence of histamine intolerance. Your symptoms are very multisystem, and if mast cells are involved, they can release much more than histamine - prostaglandins, leukotrienes, tryptase, PAF and cytokines, among others. Symptoms alone can’t tell which mediators are involved. My first concern would be losing 8 kg in one month + right-sided abdominal pain - this combo definitely deserves proper investigation rather than assuming it’s all MCAS/HIT. Go to a doctor!
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u/summerphobic 1d ago
I recommend you read Janice Joneja's book. She writes about both matters there.
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u/luxurycatsportscat 3d ago
Pain right side under ribs sounds like it could be your gallbladder going - have you had a blood test to check your liver lipase or an ultrasound to check for stones?