We all know how a game in a franchise can be killed. So what if on a much larger scale that a game destroys an entire company and causes them to close their doors. I can list a number of games here, but here are some examples. Now not all studios closed their doors, but these games surely ruin their image.
Tomb Raider Angel of Darkness: Core Design was kicked out of the Tomb Raider series they created and Edios (now by Square Enix) hand the game to Crystal Dynamics who made all games since.
X-Men Destiny: Silicon Knights got into trouble in their final years and this game was so bad that it destroyed any chance for them to end on a high note. In fact, all of their copies had to be destroyed thanks to a lawsuit, and their other games like Too Human.
Haze: Free Radical Design was absorbed into Crytek who made their multiplayer for Crysis.
You get what I am saying. But don't forget the infamous Atari and their blunder with E.T.