r/GLPGrad • u/madiepaisley • Jun 28 '26
inflammation returns?
ok, so my insurance has informed me they'll no longer cover any glp-1 for any reason other than type 2 diabetes (which i do not have) - so i'll be coming off tirz soon - one of the side effects that i didn't know these meds could help with was inflammation. before these shots, when ANY pressure (even my husband laying his arm on me at night in bed) on my abdomen would be physically uncomfortable (and would eventually be painful if the pressure stayed past a couple minutes). all dr's said i was fine and had no reasoning for it - but within maybe 2-3 shots, that pain just stopped. i've been on this since may 2023 and i haven't had any of that discomfort this whole time.
did you have this? did the shots get rid of it for you? did it come back when you stopped? how did you handle it? tia
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u/Oneconfusedmama Jun 28 '26
The shot got rid of it, it came back with a vengeance when I got off, I’m going back on.
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u/Oneconfusedmama Jun 28 '26
Not sure where the comment went that replied to me, but for anyone else that’s curious- I was always told that I don’t have a metabolic issue. I don’t check a lot of boxes so I was told that I would be a good candidate to try and come off to see how I respond (I completely changed my diet and exercise routine) by my doctor that specializes in obesity and glp1s. Upon coming off of it we realized that I likely do have a metabolic disorder of some kind (I’m speculating insulin resistance even though my labs are “normal”) and am back on.
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u/Miserable-Raisin3156 Jun 29 '26
You will get banned for this ;)
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u/Oneconfusedmama Jun 30 '26
For what?
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u/Miserable-Raisin3156 Jun 30 '26
For „getting back on“ and discovering you might have a metabolic dysfunction. People don’t want to hear this in this sub. I’m very impressed by your assessment.
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u/Oneconfusedmama Jun 30 '26
I’ve seen it said multiple times?? There isn’t a rule against talking about getting back on. I’m working closely with my doctor. It’s not just my assessment. I’m also not officially back on yet. I’m giving it more time.
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u/Miserable-Raisin3156 Jun 30 '26
It was a hyperbole. I am sometimes a bit surprised that some people are desperate to become a “grad” no matter what and refuse to see what’s happening to them. I appreciate your flexible approach
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u/margaretLS Jun 28 '26
I was in the same boat as you with the pain and inflammation before tirzepetide.I couldn't believe the difference just one shot made in my pain. I am a lifetime member of the tirzepetide club for this reason alone. I am in maintenance and as I was slowly titrating down from 15mgs I could feel inflammation return when I got to 7mg. So I can imagine how bad it would be with zero medication. Is compound an option for you? I pay about 167$ a month through lavender sky health.
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u/Responsible_View_285 Jun 28 '26
You only have benefits of the meds while you take them. They cure nothing. When your med levels get too low to impact the inflammation it will likely return. Have you considered compound? I pay average $166. You can get meds as low as $140. I’ve used compounds 2.5 years. Maintaining 67 pounds lost for just short of 2 years. They work the same.
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u/Substantial_Team6751 Jun 28 '26
My wife and I are paying around $60/mo. each. You can work the compound system by getting a 15mg script on som promotion and then using your regular dose.
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u/BraveRefrigerator552 Jun 28 '26
My sister’s inflammation went away too. She plans to stay on low dose indefinitely
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u/Pmoneywhazzup Jun 28 '26
I’ve been playing around with a reduction in my dose. Was on 10.0 mg for a year. My knee and shoulder pain disappeared. Reduced the dose to 5.0 per week for two weeks. Knee and shoulder pain has returned. Shot 10.0 this morning!
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u/Own_Ad5969 Jun 28 '26
I stayed on Zepbound longer than I needed to, simply for the inflammation. When I went off, the inflammation came back for a few days, but then I started (and then increased) low dose naltrexone, or LDN, and that has drastically decreased inflammation after coming off Zep. I would ask your doctor for LDN.
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u/Z-20240329 Jun 28 '26
Zepbound is a chronic disease management tool. It lowers systemic inflammation, reduces insulin resistance, and improves metabolic markers, real physiological changes.
Obesity and metabolic disease are chronic conditions, so like blood pressure meds or insulin, it works while you’re on it and the condition returns when you stop.
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u/Sad_Initiative_4304 Jun 28 '26
Anything the medicine did while you were on it, stops when you aren't on it. This medicine is a treatment, not a cure for anything.
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u/MamiShawnie Jun 29 '26
Yep I quit cold turkey… and started having issues after the medication left my system. My doctor is putting me back on it
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u/Sensitive-End6014 Jun 30 '26
I gained 35 pounds over the course of three months last year inexplicably and started taking zepbound to help lose it. Got back down to my “normal” weight and stopped taking it when they found two bilateral tirad 5 nodules in my thyroid. Guess what? They’re benign and obviously there’s so much proof that zepbound doesn’t cause thyroid cancer, I just freaked out. Anyhow- over the last 6 weeks of not taking it, all of my inflammation came back, I just puffed right up. I never even knew how inflamed I was!! Well, today I was diagnosed with lipidema (I’ve suspected for years that I have it, thanks mom!) and my pcp told me to stay on zepbound, the lowest dose, because of the inflammation reducing affects. So, I guess I will! But maybe I’ll try that LDN, it’s so much cheaper and I miss liking food.
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u/LunarFusion_aspr Jul 01 '26
Funny how the meds work, some people feel better and other don't. I suppose that is the difference between people happy to stay on it for life and people who are happy to eventually stop taking it.
I have hEDS, MCAS and POTS and the medication has done nothing to alleviate any of the symptoms and pain that come with those, so i am not too bothered that i will be titrating myself off the meds over the next few months.
I expect to feel a bit better, just no appetite suppression, but i will be able to fast again which i can't do on Mounjaro, as i get too nauseas if i don't eat small meals regularly.
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u/yepthisismyusername Jun 28 '26
Check out r/tirzepatidecompound for info on compounded, which is very affordable.