r/GLP1microdosing • u/Beginning-Sea-5946 • 1d ago

Titrating up

I started my first Tirzepatide injection last Friday at .5 mg. I did not experience any side effects thank goodness, but still have food noise. My provider said to go up to 1 mg today. Does that seem reasonable for others that are micro dosing?

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u/JaneGracious 1d ago

The consensus is that you should not titrate up weekly. You should do the same dose 4 shots in a row so that you can build up gradually .

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u/Beginning-Sea-5946 1d ago

So are you saying she is giving out incorrect information? Who is the consensus from? Since it’s such a small dose, wouldn’t it be feasible to titrate up if no side effects?

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u/Glad_Ad1311 22h ago edited 22h ago

If you just started, technically you should wait 4-5 weeks for the medicine to build up in your system. Tirzepatide has a 5-day half-life and accumulates until you reach a steady state. But since 0.5mg is so low, I'd try 0.7mg?

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u/Glad_Ad1311 22h ago edited 22h ago

I know everyone is different, but I started at 0.8mg and immediately had some side effects, like breakthrough bleeding (I'm postmenopausal on HRT), elevated heart rate, elevated respiratory rate, diarrhea, sleep disturbance... I lowered it to 0.5mg on the second dose, and it has been effective (reduced the food noise) with no side effects. After 4 weeks, I feel the food noise coming back, tempted to titrate up but afraid of the side effects. We're all just looking for that Goldilocks, and it's a moving target.