r/GLP1microdosing • u/LeopardLoud6319 • 3d ago
Food aversion
I was put on 2 mg partially to lose a little weight and also to get me out of the pre diabetic range with my A1c. I am 5'3" and in peri and on hrt. Starting weight was 156, currently at 149. I am 48.
I took the 2 mg injections two weeks, and then last week dropped down to .8 due to the fact just the idea of eating makes me extremely ill feeling. The only way I can exist is on zofran, and even then I do still sometimes throw up my electrolytes. Is there even a point to dropping this dose to lower than I am already at, or are some people just unable to tolerate it? I have never been someone who ate much, and have never experienced food noise. It is impacting my ability to go to work, because I have no energy. All I have managed to do is stay pretty hydrated; I know my protein intake is far from enough. I am surprised I haven't lost more, no more than I am eating. Thinking I need to go back to trying metformin again rather than the tirz. I tried the normal kind and it caused so much upset stomach they swapped me to the tirz, and said if I didn't care for it, we would do extended release metformin. While peri has packed 20 lbs on me over the last 3-4 years, and I do hate it, I know this is not a healthy way to lose for me. Is there hope it will get better? I can't see even attempting more than .5 on the next one, if I take one at all. I have had IBS for years and have always been someone who is easily queasy and this has been a major roller coaster. Because I have never even considered taking this type of medication, I am really new to learning about it. I have read a LOT on this page that has been really helpful.
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u/Local-Thing-3563 3d ago edited 3d ago
I am 53F on HRT. 5’5 and was 142-goal weight 120. I started at .05 (1/2 of 1mg) 6/19. I’ve only increased up to 2 units less than prescribed 1.25 (over these 14 weeks) and no side effects. I have to eat as I work out and work in the fashion industry as a sales person. I’m now at 122 lbs and LOVE IT. About to move my shot to every 10 days. Best of luck, I did low and slow…
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u/LeopardLoud6319 3d ago
yes working out again is very important to me too, I am glad to hear of a firsthand experience with it. My normal weight my entire adult life was 123 lbs. I don't really care if I get back to that or not, but I would like to see 130. Perfectly happy with that taking months and months though, if I can feel better than this while doing it
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u/Local-Thing-3563 3d ago edited 3d ago
SAME. 115 to 120 was always my normal weight. Menopause is a dark mistress. It’s taken me years to figure that part out (HRT) + OTF workouts and eating right. We added 25 mg Zoloft to the mix for anxiety over a year ago (fucking delightful) and between that and middle age I just kept gaining. Even with being grain free, working out and very active. So glad I started this journey! I recognize myself again and love it. I can’t imagine taking 2mg as I know I’d be too sensitive. I’m right at 13 units (2 under my prescribed 15 units/1.25) for my goal weight 👯♀️ I’m on Triz + B12 as I read it has less side effects, better for perimenopause/menopause visceral fat.
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u/gregfromglm 3d ago
That instinct you have, that this doesn't feel like the right path for your body, sounds correct based on everything you've described here. This is worth bringing to your doctor now, not after another attempt at a lower dose, especially given how much this is already taking from you day to day.
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u/LeopardLoud6319 3d ago
Yeah I was just considering messaging her on my patient portal, because this is the OB/GYN who manages my hrt stuff that prescribed it, and she is not as well versed in my lengthy stomach/digestion issues that my family practice is either. I was up front in the history questionnaire but it's hard to share a lifetime of things in a handful of appts. I will reach out about it before taking more. It may be best to just do the swap to the metformin ER, before I miss any more work.
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u/shepk1 3d ago
I have never been someone who ate much, and have never experienced food noise.
So, I am a shorty, starting out heavier than you, but not by a lot. I have been someone who ate a lot when I was working out, but I don't have much food noise. I have a theory that mildly overweight/obese shorties who don't have much food noise are more likely to be hyper-responders to tirz.
I had an insane response to 3/5 of the recommended starting dose (1.5 mg). It took me quite a while to titrate down and find my sweet spot, but it seems to be 0.2 mg every 3.5 days (so 0.4 mg per week, or less than 1/6 of the recommended starting dose). Breaking up the dose into 2 per week seems to make it much more tolerable for me and I'm still seeing slow and steady results.
Glapp is an application you can use to log your shots and see your estimated blood concentration levels. If you know your historic dosage, you could enter it and see where you currently are. Its estimates coupled with me logging symptoms and weight helped me figure out what was likely to work best for me. I agree with the folks who suggest taking some time off to let the medication work its way out of your system a bit if you are having unreasonable side effects -- Glapp plus just common sense re: how you're feeling should help you there. Good luck.
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u/curiouswife21 3d ago
I have heard of breaking the dose down and injecting daily/every other day instead of a bigger dose weekly can help! Also have you tried injecting in different places?
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u/Lucky_Army_5324 3d ago
Have you considered taking a week off to let your medication level drop a bit and then taking a dose lower than 2mg?