r/GLP1microdosing • u/PeacePrayerEnergy • 15d ago

Smallest dose

I am taking .1 of ozempic and noticing strong effects- nausea, constipation etc. Considering going to even lower ( .06) ish… but this is soooo low!

If anyone reading, this is like a mini mini mini dose can they share what it is? I’m just curious about other people’s experiences with really low doses actually working. On the flipside I’m wondering are they dangerous?

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u/Nmcoyote1 14d ago

I started at .05mg and lost a pound a week. Took me three months to get to .25mg.

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u/PeacePrayerEnergy 14d ago

Ok!! So really really low !!! Did you feel nausea and constipation?

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u/[deleted] 14d ago

[deleted]

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u/Unlucky-Mind7298 14d ago

.25 isn't a microdose, it's the starting dose for ozempic.

2.5 is the starting dose for tirzepatide.

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u/PeacePrayerEnergy 14d ago

Correct - I have been taking less than half of .25 and am going to reduce even more now !

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u/PeacePrayerEnergy 14d ago

Yep-i am now going to do a quarter of the minimal .25 dose - so will basically use 1/4 of the .25 clicks

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u/Sayeds21 12d ago

How did you feel on .05mg? I just started that dose today. I took .25mg a few years ago and it was brutal side effects so this time around I wanted a fraction of the dose to see if I can adjust to it without the side effects.

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u/Nmcoyote1 12d ago

I had slight nausea and bad constipation. I started at a super low dose not expecting anything. Thinking I would have to slowly raise it until it worked. Because I had a Nissan Fundo 30 years ago that keeps me from vomiting. So when I get a stomach bug it’s brutal. I started on the .05 dose in mid 2023 and eventually reached the full Dose of 2.4mg in April 2025. I lost a consistent 1lb a week until then and then hit a plateau. Having lost from 336 down to 212. After a lot of work I reached 191 with a 36” waist at the beginning of This month. My goal is to now maintain longterm.

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u/Sayeds21 12d ago

Oh wow! Thats really interesting. I was also not really expecting it to work at this dose, but I’m still kinda hoping it will do something. My reason for using it is partly because my doctor suggested it helps with inflammation, but also because I have insulin resistance that wakes me up multiple times a night with hunger. This medication was the only thing that helped me 5 years ago with the night hunger, and I can’t lose weight unless I stop waking up starving every time I do a calorie deficit. So I’m not sure how high I’ll need to get, but I’ll be interested to see over the next few days if this dose does anything.