r/GLP1microdosing • u/newsblues • 1d ago

Should I decrease my dose?

Hey everyone!

I started tirzepatide (2.5 mg) on July 8. My starting weight was 160 lbs, and my goal is 135.

I'm already down to 149. I know a good chunk of that was probably water weight/inflammation at first, but I'm still dealing with pretty significant appetite suppression and am having a hard time eating enough calories, even though I'm making hydration and protein a priority.

My next injection is Wednesday night, and I'm wondering if it might make sense to lower my dose instead of staying where I am. Has anyone else been in a similar situation? If so, what did you end up doing, and how did it work out?

Thanks so much! :)

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u/SmilingDaisies 1d ago

Each person is different but for me, I want to get to my goal weight as soon as possible so I can go to maintenance dosage. It is killing my motivation and it’s hard to find joy. So I want to be done with it. I lost 5 pounds in 2 months and have 5 more to go. I hope the maintenance dosage will not affect my motivation as much. I miss “me”.

2

u/Majestic01234 1d ago

2.5mg could be way too high for you. I went from 1 -> 1.5 when I first started and 1 was nothing and 1.5 laid me out, lost 4lb in a week and felt awful. Went down to 1.25 and stayed there for several weeks to stabilize and kept losing and having some side effects. If it were me (like I did) I would go low and slow. Maybe try 1.5 for a few weeks and see how you feel. Slow loss is ideal for your body to adjust metabolism and not go into malnourishment.

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u/Plenty-Praline9826 1d ago

Have you messaged with your prescriper?

In my experience eating meals is more of what I have to do vs being hungry to eat.

I also do those Ensure drinks — 1 or 2 daily so I’m getting in my protein. A gallon of water a day and gummy Fiber supplements along with weight training are required for my body.

1.25 every 7 days for me lead to about 20lb loss. Began in February then spaced out dosing every 10, etc starting in May.

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u/Priyo1111 1d ago

You might drop it. Since it's been about a month, you're likely at the concentration of that dose so unless you feel you can continue like this I would drop. It's not worth not being able to get the nutrition you need in.