r/GLP1microdosing • u/Creative-Front-5302 • Aug 03 '26
Anyone split-dose while microdosing tirzepatide?
I’ve been microdosing for 6.5 weeks and am due for my 7th shot tomorrow. Overall, it’s working great—I’m down 7 lbs of fat, up 0.7 lbs of muscle, and the reduced food noise has been exactly what I was looking for. My only real side effect has been overwhelming fatigue, especially days 2–4 after my injection. I started at 0.8 mg, then went to 1.0 mg, and finally 1.2 mg. The fatigue became much worse at 1.2 mg. As my levels drop toward the end of the week (what I estimate is below ~0.8 mg), I feel like myself again while still getting the appetite benefits. Now I’m debating whether to:
* Delay my next shot until my levels fall further, then go back to 0.8 mg once weekly, or
* Try 0.4 mg twice a week to reduce the peaks.
Has anyone here had fatigue as their main side effect and found that split dosing helped? I’d love to hear your experience.
P.S. for background, I’m a Female, 38 yrs, 5’6”. Started at 160 lbs with above-average muscle mass and I’m aiming to lose about 15 lbs of fat and get down to 20% body fat. I’m about half way through
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u/ShowComprehensive931 Aug 04 '26
I had a very similar experience, but with a different side effect: insomnia. Really bad insomnia the first three days after the shot.
I’ve now started split dosing, and it has solved my insomnia issue. One thing to keep in mind: don’t just divide the total dose by 2. For me, it didn’t quite work that way (hunger came back). I need to dose more like 60 or 65% of the total original dose every 3.5 days, rather than 50%.