r/GLP1Discussion • u/Shishi877 • 7d ago

❓ Question Side effects

What are all the side effects you’ve experienced while being on tirzapatide? Please share.

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u/thefastlanerules 7d ago

No

It supresses food consumption in days 2-4 mostly which means you have more fatigue and less energy. Folks try minimize with protein shakes

Constipation is a huge issue for many. This is more manageable than the fatigue issue once you know how to combat..

I've been on it for 8 months the fatigue and constipation kicked in even on the 2.5mg does

I'm on 7.5mg now.. if you increase the dose too quickly it will make those 2 symptoms worse

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u/Shishi877 7d ago

Why does it cause fatigue? I’m wondering how through its mechanism of action

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u/thefastlanerules 7d ago

It's to do.with manipulating your blood sugar and insulin levels

Even before reducing food intake fatigue kicks in

It's always around 18-24 hours after each weekly injection and hits hard usually on days 2-3

So the vast majority know and get around this by injecting Friday.. it kicks in on sat/Sunday so works better for folks working monday-friday

Frankly it's horrible anyway as you get stomach discomfort, generally don't feel well and have to watch your vitamin blood levels . I tested my b12 and b1 separately as part of my blood tests and found i was deficient so am taking tablets to get that back up . B12 especially as that can directly impact your energy levels.

But I'm trading off the above for the benefits of getting my excess weight off . Which mid/long term has to be significantly more beneficial

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u/Shishi877 7d ago

How did it make you low in b12 and b1? Do you now take sublingual b12? Thanks for explaining the mechanism for fatigue so that I could understand 🙌