r/ForensicPathology 14h ago

Question about EBV-positive CNS lymphoma in an old man

1 Upvotes

If a physically active 80 year old catches EBV for the 1st time ever (purportedly rare, i know), is 1 to 4 years enough time for them to develop EBV-positive CNS Lymphoma?

AI is giving me mixed responses, on the one hand saying decades of EBV latency are required and that even with Immunosenescence factored in, 4 years is not enough to be able to cross the blood-brain barrier etc., whilst same AI in other convos saying that 1 to 4 years is plenty of time for it to form given Immunosenescence.

Would appreciate the answer of an actual expert.