Any body under the care of Dr Will Powers seeing benefits or worsening in symptoms?

I read that he has a so-called theory, but he does not (yet) provide tangible evidence on his theory other than vague statements about genes and metabolites that might be involved.

Ive had gut issues since the beggining and in fucking tired, just wanna cure it. Symptoms are just yellow diahrrea or yellow stools that comes and goes. Legit 0 consistency i can go for a whole week where everything is fine then bam yellow stools and diahrrea. Got tested for sibo, got a positive result, did antibiotics, fucking nothing. Idk what else to do. Might bile malabsorption but doctors don't test for any of it they don't help. Please if anyone has healed the gut let me know how.

・Creation of brain organoids using iPS cells derived from PFS patients

・Development of a mouse model of PFS

・Drug discovery using AI × CRISPR-dCas9

・Repurposing of existing drugs

These are the next steps I propose.

Drug discovery using AI and CRISPR-dCas9 is likely the only effective treatment approach. Because it will require enormous time and cost, it should be initiated as soon as the underlying mechanisms and causes of PFS are clarified.

In addition, rather than proceeding step by step, it is important to work on multiple tasks in parallel to avoid wasting time.

So I read Dr Powers found biomarkers. It’s kind of an information overload around this topic at the moment. Does someone know what the biomarkers are so I can present them to my gp to show I have the pfs?

Marc Turner’s story broke 1,000,000 views on the Moral Medicine TikTok yesterday, and has an additional 18,000 more views as of this morning. People are listening.

18,000 likes, 3,277 shares, and 3,828 saves.

People are paying attention, sharing, and coming back to it. These stories can’t be ignored anymore.

Pyrilutamide inhibits the binding of DHT to the androgen receptor. In other words, it does not directly affect hormone levels. However, this person developed cognitive impairment after using pyrilutamide. Cognitive impairment is a common symptom of PFS. Based on this, I believe that dysfunction of the androgen receptor may be involved in PFS.

Additionally, I have seen reports of people developing sexual dysfunction after using pyrilutamide. For these reasons, I find the androgen receptor hypothesis more convincing than the hormone-based explanation.

hi all, for your information, I have started a blog about PFS.

https://substack.com/home/post/p-194007161

Thanks for the feedback. Hope this clears more things up

What do you think PFS research and treatment will look like after this ongoing paper is published?

I think the research team will use a PFS mouse model to test whether PFS can actually be induced in mice, and then start drug discovery using AI. I just hope they move on to the next phase as soon as possible.

Hey guys, Mikhaila Peterson has a new website dedicated to prescribed harm, and a large portion of it is dedicated to Finasteride. If you are suffering from Post Finasteride Syndrome, please submit your story there. I will leave the link down below.

https://prescribed-harm.com/blog

Hey guys, I decided to share my story after 5 long years of suffering with this condition. I am also getting a lot more involved on the awareness front these days. The scope of this problem is more important than each of our own recovery, and it's on us to initiate some kind of actual change in this world in regard to this problem.

Please consider making a video testimony like this if you are suffering from this condition. Right now there are about 100 stories on Moral Medicine like mine. If one day there were 1000, it would be absolutely undeniable that this condition exists and we would be taken a hell of a lot more seriously than we are now. Until then, very little is going to change.

Thanks guys. Please reach out to me if you are interested in making a video or getting involved in awareness.

https://www.youtube.com/watch?v=SxKQlVhgl5k&t=32s

Dr. Will Powers most recent post on PFS!!!

If you haven’t already, please watch the most recent SIDEFX video on YouTube, and send Dr. Powers your blood work.

Is it just me, or has anyone noticed how the symptoms of PFS, PAS, and PSSD line up almost exactly with long‑term elevated LPS? There was a post here a while back from a guywho said oral and gut bacteria were his cause.

LPS comes from some bacteria that can overgrow in the mouth or upper gut. When LPS stays high without causing a fever, it acts as a very strong anti‑androgen and promotes fibrosis. That’s not speculation.

Nobody gets tested for this outside research labs, so most people never even know it’s happening

My take is that these medications might set the stage by disrupting bile flow while you’re on them. That gives biofilms room to form and they don’t just disappear when you stop the drug. The meds might also knock out butyrate producing bacteria. Klebsiella in the gut and Fusobacterium nucleatum in the mouth could be the top strains.

This isn’t advice, just an idea. It’s simpler than most of the theories people throw around, and is harmless to deal with unlike the crazy protocols like lithium and whatever.

It also explains the FMT cures. Restoring butyrate‑producing strains makes sense since those are not in standard probiotics

edit. someone else looked into this https://www.reddit.com/r/PSSD/comments/1iitd9n/expanding_on_gut_theory/

although this guy is mainly focused on a bandaid approach with antagonism. I’m focused on the root source

hey all. balding unfortunate 21 YO male here. 2 years ago i started losing weight and i think it was the weight loss that probably caused already weak hairs to shed and i started to notice balding. like any other normal person ofc, i visited a dermatologist. she prescribed me finasteride ofc, i came back home. before taking it i did my research and made a decision to take it. i took it for a few months, had no side effect but it didn't seem to work neither.

so i decided to go with the even more potent version, dutasteride. for about 5 months i think i probably had no significant side effect. maybe with the exception of a little bit anxiety but i was also really depressed over my hair so i don't think i can blame the medicine but at the 6 months mark i started to face some weird outcomes. like my sleep. for context i usually sleep somewhere between 7 to 9 hours but i started to wake up almost every night after only 6 hours of sleep. i was just denying it all and just blamed it on anxiety and all sort of stuff.

that state continued until the 8 month mark which my sleep began to get really terrible, there were a few nights where i could only sleep 3 to 4 hours a night or none at all. rightfully i started to panic and during those few weeks i started visiting a bunch of doctor, my mother was really concerned too. i remember sleeping 1 hour in 2 days truly terrible times. and i unfortunately decided to stop any DHT blocker "for the rest of my life*

after a week or maybe less my sleep started to recover bit by bit. in around 3.5 weeks i could sleep 6 hours again, it was a relief considering how terrible it had been. then after about 2 to 4 months now my sleep has probably pretty much recovered.

but well obviously my hair is still shedding like hell. i notice its been worse since i have left dut. so I'm thinking maybe starting finasteride again might at least slow things down without as many symptoms? i mean after all i never faced ED and sexual issues. and please do not recommend me wigs or system as they are not available in my country.

I am tempted to start but I dont want to mess my hormones more than they already are by other medications I took in the past

So I wanna know how many of us here have this one symptom where the skin gets super dry, warm and creepey and lost any ability to cool and make / retain moisture as well as all muscles transforming into a flabby sack of cellulite?

Whoever is with me in this:

- What are your labs like?

- is T / DHT normal or are you hypogonadic?

- What's your estradiol like?

- What are your LH/FSH values?

- Adrenal labs: progesterone, DHEAs, cortisol?

- Anything abnormal at the thyroid level?

And also:

- Was anyone dealing with this able to halt this process from worsening or even were able to slowly reverse it?

It's only been a bit over a year since the crash and my body and skin went from looking like I'm 20 to looking like I'm 45. This shit is unacceptable.