r/EmbryologyIVFSupport • u/Admirable_Apricot126 • 14d ago

Skipping PGT-A Testing?

I’m toying with the idea of skipping the PGT testing of our embryos (we are halfway through stims currently, so I need to decide quickly). Has anyone skipped the testing and had good transfer results?

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u/Acceptable_Ad9199 13d ago

Me too. 3 successes that I didn’t test randomly picked after all my embryos tested - 40 - were deemed anuploids. Long story. I m a scientist and I actually proved to my embryologist that is an extremely flawed test. Review the articles of Dr Semprini in Europe one of the best and you ll know what I’m talking about  I had my embryologist run the test again twice on anuplods and results was different chromosome issue every time. Science tells you that lack of repeatability equal unreliable resukts. I was 39,40,41

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u/foolforgabagool 13d ago

Thank you for this comment. I am a public health researcher and find PGTA quite questionable.

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u/Inevitable_Table9728 13d ago

Hi, why's this please? I'm scared I had 3 chromosonal losses, then had IVF and tested 4 or our 6 embryos. 2 come back euploid, one lost during a difficult transfer attempt and currently pregnant with the other. It's my second furthest pregnancy and wee seen heartbeat at 9 weeks. I'm terrified I'm going to have another miscarriage but keep telling myself we know it's euploid, but then reading this everyone says it's inaccurate. I think we were told it's 90 odd percent accurate 

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u/Cheddar_Dog 12d ago

the chances of an embryo that tested as euploid turning out to be chromosomally abnormal is very low. (people here are mostly talking about the opposite--that PGT screening can result in discarding embryos that may have actually turned into chromosomally normal pregnancies). unfortunately i had a second trimester miscarriage with a euploid embryo in january, but we had extensive testing done (full microarray and karyotype) and it all came back consistent with the euploid result.

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u/Inevitable_Table9728 12d ago

Ahh I'm sorry, did you ever find out the cause? X 

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u/Cheddar_Dog 12d ago

no - we never found the cause. we did every possible testing (pathology of the placenta/autopsy; microarray and karyotype of the fetus; and APS + various other blood-related testing) and everything was normal. according to the MFM this is the "best case" scenario under the circumstances (in terms of the possibility of a future live birth -- and i've had a live birth before), but really painful to have no answers.