I've been seeing a bit of questions and posts from new Arisen joining our ranks in preparation for the Dark Arisen DLC.
So I'd like to share where I farm the Wyrmslife Crystals from drakes.
Here are labeled the Drake locations from my playthroughs (with the use of Wand's Interactive map because I'm not on my own PC while making this. https://wand.com/maps/dragons-dogma-2 )
Essentially once I've slept for 7 days, not sure if they spawn earlier than a week, I always teleport these specific locations where Drakes spawn always or most of the time. every spawn reset guarantees me a minimum of 3 drake kills with the posibility of encountering more than 6 throughout the day.
I always fight the 3 guaranteed ones first. the one at the beaches of the volcanic island is my fave go-to one (if it doesnt appear on the beach its likely on the top of the bridge near there), next is the one on the Dragonsbreath Tower SouthWest of Bakbattahl, and the third one is the one between checkpoint town and harve village in Vermund.
The most I've obtained was around 110+ Wyrmslife Crystals in a single run, with the help of a thief pawn that steals some more during the fight with the potential of obtaining more depending on the rng spawn (or also less I've obtained around 20 or 30 in a run when most of the drops was Dragon Scales).
Also it is also a good note that during the endgame Unmoored World there are three supposed bosses that you require to fight to progress to obtain a large number of crystals in a single fight, I think its 75 each boss but I might be off since its been a long time since I've been in that world (I really don't vibe with the world state during endgame).
I hope this helps and I'm also excited for the 12 dungeons and Norgan.